Figure 2. Analysis of the spatial expression patterns of the fgf1, fgf4, and fgf8 subfamilies. A: Whole mount in situ hybridisations of fgf1 and fgf2 at the indicated stages. B: Whole mount in situ hybridisations of fgf4 and fgf6 at the indicated stages. C: Whole mount in situ hybridisations of fgf8. For stage 10.5, the images are vegetal views; for stage 15, the images are dorsal views; and for stage 23, 28, 35, and 40, the images are lateral views (anterior is left, posterior is right, dorsal is up, and ventral is down). A schematic representation of a Xenopus embryo at stage 28 with the different embryonic tissues labelled is presented in Supp. Figure S3. Image published in: Lea R et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons.Gene Synonyms Species Stage(s) Tissue fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 10.5 marginal zone fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 10.5 mesoderm marginal zone fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 10.5 marginal zone mesoderm fgf8 AIGF, FGF-8, fgf8a, fgf-8b, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. tropicalis Throughout NF stage 10.5 marginal zone fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 15 embryo dorsal fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 15 paraxial mesoderm fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 15 mesoderm posterior fgf8 AIGF, FGF-8, fgf8a, fgf-8b, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. tropicalis Throughout NF stage 15 neural crest cranial neural crest neural plate pre-chordal neural plate posterior neuroectoderm anterior neural ridge fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 23 notochord eye fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 23 presomitic mesoderm head region fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 23 tail bud eye primordium somite paraxial mesoderm fgf8 AIGF, FGF-8, fgf8a, fgf-8b, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. tropicalis Throughout NF stage 23 forebrain presomitic mesoderm branchial arch pronephric kidney neural crest cranial neural crest somite paraxial mesoderm midbrain-hindbrain boundary neuroectoderm fgf6 fgf-6 X. tropicalis Sometime during NF stage 23 to NF stage 35 and 36 somite paraxial mesoderm head region fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 28 forebrain neural tube otic vesicle ventricular zone eye olfactory placode fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 28 presomitic mesoderm eye head region fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 28 tail bud otic vesicle optic vesicle somite paraxial mesoderm midbrain-hindbrain boundary branchial arch tail tip fgf8 AIGF, FGF-8, fgf8a, fgf-8b, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. tropicalis Throughout NF stage 28 to NF stage 35 and 36 tail bud forebrain mesoderm branchial arch pronephric kidney cranial neural crest somite paraxial mesoderm heart primordium head region chordoneural hinge lateral plate mesoderm midbrain-hindbrain boundary pineal gland fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 35 and 36 forebrain neural tube otic vesicle ventricular zone head region hindbrain fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 35 and 36 tail bud mesoderm branchial arch pronephric kidney otic vesicle neural crest fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 35 and 36 tail bud branchial arch otic vesicle optic vesicle somite paraxial mesoderm midbrain-hindbrain boundary tail tip fgf1 acidic fgf, aFGF, fgf-1, HBGF-1 X. tropicalis Throughout NF stage 40 forebrain otic vesicle hindbrain pharyngeal region head fin fgf2 basic fgf, bfgf, fgf-2, HBGF-2, xfgf2 X. tropicalis Throughout NF stage 40 tail bud branchial arch head mesoderm otic vesicle fgf4 efgf, fgf-4, fgf4-a, fgf4-b, fgfe, HBGF-4, XEFGF, Xfgf-4, Xfgf4 X. tropicalis Throughout NF stage 40 paraxial mesoderm head region midbrain-hindbrain boundary tail bud branchial arch otic vesicle optic vesicle somite fgf6 fgf-6 X. tropicalis Throughout NF stage 40 somite paraxial mesoderm head region fgf8 AIGF, FGF-8, fgf8a, fgf-8b, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. tropicalis Throughout NF stage 40 tail bud forebrain neural tube branchial arch pronephric kidney somite paraxial mesoderm midbrain-hindbrain boundary heart primordium otic vesicle eye chordoneural hinge posterior wall of neurenteric canal pharyngeal arch mandibular arch hyoid arch
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