Xenbase Image ID: 44588

Figure 4. Expression patterns of selected retinoic acid receptor (RAR) target genes. Expression pattern of selected upregulated genes at stage 18 and stage 22 were determined by whole-mount in situ hybridization. Embryos were hybridized with probes made from indicated expressed sequence tag (EST) clones. The staining patterns in whole and sectioned embryos were summarized and used to categorize the genes broadly into four groups (group 1, 2, 3, and 4) by expression patterns. The signature staining of group 1 is present in the neural tube, neural crest, and optic anlagen; the staining patterns of group 2 are similar to those of group 1 but absent from the neural crest. Group 3 genes show staining in the neural tube but not in the optic anlagen. Group 4 genes have staining in the lateral plate mesoderm where RALDH2 is predominantly expressed. A, B, and C are in group 1; D, E, and F are in group 2; G, H, and I are in group 3; and J, K, and L are in group 4. A1-L1, A3-L3, M1-R1, and M2-R2: dorsal view; A2-I2 and A4-I4: anterior view; C6 and J2-L2: lateral view; C7: ventral view; C5: J4-L4 and M3-R3: sagittal section of stage 22 embryos. VLCS, very-long-chain acyl-CoA synthetase; Hypothetical, similar to ESTs from other organisms; Unidentified, no significant similarity to database sequences from any organism; Sm, somites; rp, roof plate of the neural tube; no, notochord; nt, the neural tube. Image published in: Arima K et al. (2005) Copyright © 2005. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue slc12a1.L Na-K-2Cl cotransporter, NKCC-2, NKCC2, XNKCC2 X. laevis Throughout NF stage 18 neural crest neural tube cranial neural crest neural plate pre-chordal neural plate chordal neural plate migratory neural crest cell intermediate mesoderm slc27a2.L acsvl1, facvl1, fatp2, vlacs, vlcs X. laevis Throughout NF stage 18 cranial neural crest migratory neural crest cell mandibular crest hyoid crest branchial crest pkdcc.2.S pkdcc2, sgk493, vlk X. laevis Throughout NF stage 18 eye primordium neural plate chordal neural plate cardiac mesoderm mxi1.L mxi, xmxi1 X. laevis Throughout NF stage 18 neural plate pre-chordal neural plate chordal neural plate eye primordium cranial placode gse1.S X. laevis Throughout NF stage 18 neural plate pre-chordal neural plate chordal neural plate eye primordium nkain4.L fam77a X. laevis Throughout NF stage 18 chordal neural plate tll2.L Xld, xolloid X. laevis Throughout NF stage 18 cement gland primordium neural plate neural fold neural plate border 1a11.L big3 X. laevis Throughout NF stage 18 lateral plate mesoderm cyp11a1.S p450scc X. laevis Throughout NF stage 18 to NF stage 22 lateral plate mesoderm tfcp2l1.L crtr1, lbp-9, lbp9, tfcp2l1-a, tfcp2l1-b, XLBP X. laevis Throughout NF stage 18 to NF stage 22 non-neural ectoderm epidermis epidermis inner layer tmem150c X. tropicalis Throughout NF stage 18 to NF stage 22 neural tube shd.L LOC121398557 X. laevis Throughout NF stage 18 to NF stage 22 neural tube neural plate nop58.L nop5, nop58-a, nop58-b, nop5/nop58 X. laevis Throughout NF stage 18 to NF stage 22 neural tube neural plate tmem38a.L duf714 X. laevis Throughout NF stage 18 to NF stage 22 somite slc38a8.L snat8 X. laevis Throughout NF stage 18 to NF stage 22 notochord slc12a1.L Na-K-2Cl cotransporter, NKCC-2, NKCC2, XNKCC2 X. laevis Throughout NF stage 22 eye cranial neural crest neural tube posterior neural tube anterior neural tube central nervous system brain spinal cord pronephric mesenchyme neuroectoderm slc27a2.L acsvl1, facvl1, fatp2, vlacs, vlcs X. laevis Throughout NF stage 22 neural tube cranial neural crest heart primordium pkdcc.2.S pkdcc2, sgk493, vlk X. laevis Throughout NF stage 22 eye optic vesicle heart primordium olfactory placode roof plate mxi1.L mxi, xmxi1 X. laevis Throughout NF stage 22 eye neural tube posterior neural tube anterior neural tube adenohypophyseal placode brain forebrain midbrain hindbrain optic vesicle olfactory placode gse1.S X. laevis Throughout NF stage 22 neural tube posterior neural tube anterior neural tube optic vesicle adenohypophyseal placode brain forebrain midbrain hindbrain olfactory placode nkain4.L fam77a X. laevis Throughout NF stage 22 neural tube hindbrain tll2.L Xld, xolloid X. laevis Throughout NF stage 22 cement gland primordium neural tube posterior neural tube roof plate 1a11.L big3 X. laevis Throughout NF stage 22 paraxial mesoderm mesoderm Image source: Published Larger Image Printer Friendly View

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