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Fig. 7. Integrin α8β1 receptor expression at limb forming stages. (AâF) WISH of wild type tadpoles at stages 44, 45, and 47 with probes for the α8 (itga8, A, C, E) and β1 (itgb1, B, D, F) receptor subunits. (G, H) Transverse sections of α8 and (I, J) β1 WISH at stages 45 and 47. β1 expression is virtually ubiquitous. α8 integrin shows more regionalized expression at stages 44 and 45 in the liver, head cartilage and other structures before becoming broadly expressed by stage 47.