XB-IMG-49213
Xenbase Image ID: 49213
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Figure 5. Expression of Crabp1 and Crabp2 in limb development. In situ hybridisation of Crabp1 and 2 in hindlimbs (h) and forelimbs (f); dark blue stain indicates expression. A:Crabp1 is expressed weakly in the skeleton of digits I to III, as seen in the ventral view of a hindlimb at st. 56. BâJ: Crabp2 expression in developing limbs. B: At st. 50, Crabp2 is expressed in the distal half of the limb bud (white asterisk) except the most distal mesenchyme cells and the epithelium. C: At st. 51, expression is limited to the central third of the mesenchyme (white asterisk). D: By st. 52, Crabp2 is expressed in patches of cells in the proximal half of the limb (black arrow), with expression also in the forming knee region (yellow arrow). E, F: Expression at the level of the knee (yellow arrow) and autopod mesenchyme (black arrowhead), in dorsal (E) and ventro-anterior (F) views of the st. 53 hindlimb. G, H: At st. 54 and 55, interdigital expression of Crabp2 (black arrowheads) is strong and there is also expression at the knee level in the anterior (yellow arrow). I, J: Dissected forelimbs showing no clear expression of Crabp2 at st. 53 and interdigital expression beginning at st. 54. Image published in: McEwan J et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons.
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