Name: Dr. Xi He

Position: Professor of Neurology

Research Description:

Our lab is primarily interested in understanding the molecular workings of Wnt/b-catenin signaling in normal development and human pathology. In the absence of a Wnt ligand, the Axin destruction complex phosphorylates b-catenin to be degraded, preventing b-catenin from reaching the nucleus. Canonical Wnt signaling is initiated by the binding of a Wnt protein to coreceptors Frizzled and Lrp5/6, which recruits the Axin destruction complex to the membrane and allows b-catenin to accumulate and enter the nucleus to alter gene expression. Current research projects in the lab focus on:

 -Understanding the role of Wnt during development

 - Understanding the mechanism of action of key signaling components

 - Identifying novel regulators of the pathway

 - Using chemical manipulation as a therapeutic target

Lab Memberships

He Lab (Principal Investigator/Director)

Contact Information

Address:
F.M.Kirby Neurobiology Center
CLS-12064
Children's Hospital Boston
Harvard Medical School
3 Blackfan Circle
Boston, Massachusetts
02115, USA

Web Page: https://www.childrenshospital.org/research/labs/he-laboratory-research
Phone:  617-919-2257
General/Lab Fax:  617-919-2771