Name: Dr. Isabelle Vernos

Position: Research Professor

Research Description:

Research in my lab is directed at understanding the role of the microtubule network in cell organization and function. To address this question we study various microtubule-associated proteins (molecular motors and MAPs) and their regulators (kinases, phosphatases and the small GTPase Ran during M-phase). One major goal is to unravel how the self-organization of cellular components results in the morphogenesis of dynamic molecular machines. At present we are focusing on one example of self-organization: the assembly of the bipolar spindle in mitosis and meiosis.
Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001). We combine it with the use of human tissue culture cells in which we validate some of the results obtained in egg extract.

Lab Memberships

Vernos Lab (Principal Investigator/Director)

Contact Information

Web Page: https://www.crg.eu/en/programmes-groups/vernos-lab