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XB-PERS-4930
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Name: Dr. Jaeho Yoon
Position: Staff Scientist
Research Description:
I am interested in the planar cell polarity (PCP) in his preferred animal model, the developing Xenopus embryo. Polarized cellular behaviors that are governed by PCP signaling represent a vital process for orchestrating cells to form a distinct polarity axis in a tissue. This PCP signaling is driven by various stimuli such as spatial/temporal gene expression, Wnt morphogen gradients and asymmetric subcellular enrichment of PCP proteins. Since abnormal regulation of PCP signaling causes severe birth defects and defects of tissue function, the PCP process has been known as an essential feature for proper embryo development and diverse functions in many tissues. Aberrant Wnt/PCP signaling has been strongly implicated in cancer progression. Areas of Expertise Xenopus Embryogenesis Signal Transduction Eph/ephrin Planar Cell Polarity (PCP) Cell Migration Cranial Neural Crest (CNC) Development
Lab Memberships
Daar Lab
(Post-doc)
Contact Information
Address:
Daar Lab
Center for Cancer Research National Cancer Institute
Frederick, MD
USA
Web Page: http://ccr.cancer.gov/staff-directory/jaeho-yoon