Name: Cornelia de Moor

Research Description:

I have worked in RNA biology for many years and published 6 reviews and 15 research papers on the subject in internationally recognised journals. As a postgraduate student I studied the translational control of insulin like growth factor by its alternative 5' UTRs in human tissues. During my postdoctoral research, I investigated the role of translational control in Xenopus oocyte maturation and made significant contributions to the elucidation the translational repression of cyclin B1 and its activation by cytoplasmic polyadenylation. My work was instrumental in formulating the first molecular model for translational control by a 3' untranslated region, the maskin model.

In 2000, I started my own laboratory in the School of Biomedical Sciences at the University of Nottingham. My current work is on the role of the 3' end of the mRNA, especially synthesis and degradation of the poly(A) tail of the mRNA and its role in gene expression. We are using mathematical modelling, standard molecular biology techniques, as well as a number of novel techniques developed in our laboratory, such as poly(A) size fractionation and mRNA synthesis and decay modelling using multiple thiouridine labelling. My laboratory has contributed to 7 scientific papers since 2008 (march 2012).

In September 2005 I moved my laboratory from the School of Biomedical Sciences to the newly founded RNA Biology Group in the School of Pharmacy. This new environment is proving very beneficial to my research, both because of the improved research environment and the smaller teaching commitment.

Lab Memberships

British Xenopus Group (Other)
de Moor Lab (Principal Investigator/Director)

Contact Information

Address:
School of Biomedical Sciences
Room D40
Medical School
Queen's Medical Centre
Nottingham
NG7 2UH, United Kingdom

Web Page: https://www.nottingham.ac.uk/pharmacy/people/cornelia.de_moor
Phone:  44 (0)115 970 9480