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Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport. , Lee WJ, Mazigo E, Han JH , Cha SH ., Sci Rep. February 4, 2025; 15 (1): 4234.
RNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization. , Koo Y, Han W, Keum BR, Lutz L, Yun SH, Kim GH , Han JK ., Sci Rep. November 13, 2023; 13 (1): 19750.
Transmembrane protein 150b attenuates BMP signaling in the Xenopus organizer. , Keum BR, Yeo I, Koo Y, Han W, Choi SC, Kim GH , Han JK ., J Cell Physiol. August 1, 2023; 238 (8): 1850-1866.
Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis. , Wang Y, Han W, Yun S, Han J ., Sci Rep. June 23, 2023; 13 (1): 10240.
Discovery of a potent and long-acting Xenopus GLP-1-based GLP-1/glucagon/Y2 receptor triple agonist. , Yuan Y , Yan Z, Lao Q, Jiang N, Wu S , Lu Q, Han J , Zhao S., Eur J Med Chem. February 5, 2023; 247 115036.
Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/ glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity. , Li Q , Yang Q, Han J , Liu X, Fu J, Yin J., Chin J Nat Med. November 1, 2022; 20 (11): 863-872.
Design of Xenopus GLP-1-Based Long-Acting Dual GLP-1/Y2 Receptor Agonists. , Yang Q, Tang W, Sun L, Yan Z, Tang C , Yuan Y , Zhou H, Zhou F, Zhou S, Wu Q , Song P, Fang T, Xu R, Han J , Jiang N., J Med Chem. October 27, 2022; 65 (20): 14201-14220.
A GLP-1/glucagon (GCG)/CCK2 receptors tri-agonist provides new therapy for obesity and diabetes. , Zhao S, Yan Z, Du Y, Li Z, Tang C , Jing L, Sun L, Yang Q, Tang X, Yuan Y , Han J , Jiang N., Br J Pharmacol. September 1, 2022; 179 (17): 4360-4377.
Discovery of once-weekly, peptide-based selective GLP-1 and cholecystokinin 2 receptors co-agonizts. , Zhou F, Song P, Tang X, Yang Q, Zhou S, Xu R, Fang T, Jia Z, Han J ., Peptides. July 1, 2022; 153 170811.
Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents. , Yang Q, Zhou F, Tang X, Wang J , Feng H, Jiang W, Jin L, Jiang N, Yuan Y , Han J , Yan Z., Eur J Med Chem. April 5, 2022; 233 114214.
Functional characterization of Clonorchis sinensis sodium-bile acid co-transporter (CsSBAT) as a steroid sulfate transporter. , Jung H , Won JY, Park YK, Han JH , Cha SH ., Parasitol Res. January 1, 2022; 121 (1): 217-224.
Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis. , Tai X, Zhang Y , Yao J, Li X, Liu J , Han J , Lyu J, Lin G , Zhang C., Front Endocrinol (Lausanne). January 1, 2022; 13 892407.
Stapled, Long-Acting Xenopus GLP-1-Based Dual GLP-1/Glucagon Receptor Agonists with Potent Therapeutic Efficacy for Metabolic Disease. , Han C, Sun Y, Yang Q, Zhou F, Chen X , Wu L, Sun L, Han J ., Mol Pharm. August 2, 2021; 18 (8): 2906-2923.
Structural insight into BRCA1- BARD1 complex recruitment to damaged chromatin. , Dai L, Dai Y, Han J , Huang Y, Wang L, Huang J, Zhou Z., Mol Cell. July 1, 2021; 81 (13): 2765-2777.e6.
Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. , Kim J , Han W, Park T, Kim EJ , Bang I, Lee HS , Jeong Y, Roh K, Kim J , Kim JS , Kang C, Seok C, Han JK , Choi HJ., Nat Commun. October 23, 2020; 11 (1): 5357.
Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents. , Han J , Fu J, Yang Q, Zhou F, Chen X , Li C, Yin J., Eur J Med Chem. July 15, 2020; 198 112389.
The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogs xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models. , Han J , Meng T, Chen X , Han Y, Fu J, Zhou F, Fei Y, Li C., FASEB J. June 1, 2019; 33 (6): 7113-7125.
Lipidation and conformational constraining for prolonging the effects of peptides: Xenopus glucagon-like peptide 1 analogues with potent and long-acting hypoglycemic activity. , Han J , Huang Y, Chen X , Zhou F, Fei Y, Fu J., Eur J Pharm Sci. October 15, 2018; 123 111-123.
Rational design of dimeric lipidated Xenopus glucagon-like peptide 1 analogues as long-acting antihyperglycaemic agents. , Han J , Huang Y, Chen X , Zhou F, Fei Y, Fu J., Eur J Med Chem. September 5, 2018; 157 177-187.
A gene regulatory network anchored by LIM homeobox 1 for embryonic head development. , Sibbritt T, Ip CK, Khoo PL, Wilkie E, Jones V, Sun JQJ, Shen JX, Peng G, Han JJ , Jing N, Osteil P, Ramialison M, Tam PPL, Fossat N., Genesis. September 1, 2018; 56 (9): e23246.
Lithocholic Acid-Based Peptide Delivery System for an Enhanced Pharmacological and Pharmacokinetic Profile of Xenopus GLP-1 Analogs. , Han J , Chen X , Zhao L, Fu J, Sun L, Zhang Y , Zhou F, Fei Y., Mol Pharm. July 2, 2018; 15 (7): 2840-2856.
Head formation requires Dishevelled degradation that is mediated by March2 in concert with Dapper1. , Lee H , Cheong SM, Han W, Koo Y, Jo SB, Cho GS, Yang JS , Kim S, Han JK ., Development. April 10, 2018; 145 (7):
Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities. , Han J , Fei Y, Zhou F, Chen X , Zhang Y , Liu L, Fu J., Br J Pharmacol. February 1, 2018; 175 (3): 544-557.
Synthesis and pharmaceutical characterization of site specific mycophenolic acid-modified Xenopus glucagon-like peptide-1 analogs. , Han J , Fu J, Sun L, Han Y, Mao Q, Liao F, Zheng X, Zhu K ., Medchemcomm. November 7, 2017; 9 (1): 67-80.
Micellar Nanomedicine of Novel Fatty Acid Modified Xenopus Glucagon-like Peptide-1: Improved Physicochemical Characteristics and Therapeutic Utilities for Type 2 Diabetes. , Han J , Fei Y, Zhou F, Chen X , Zheng W, Fu J., Mol Pharm. November 6, 2017; 14 (11): 3954-3967.
Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. , Han J , Chen X , Wang Y, Fei Y, Zhou F, Zhang Y , Liu L, Si P, Fu J., Biochem Pharmacol. October 15, 2017; 142 155-167.
Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels. , Chae S, Lee HK , Kim YK, Jung Sim H, Ji Y, Kim C, Ismail T, Park JW , Kwon OS, Kang BS, Lee DS, Bae JS, Kim SH, Min KJ, Kyu Kwon T, Park MJ, Han JK , Kwon T , Park TJ, Lee HS ., Sci Rep. August 21, 2017; 7 (1): 8874.
Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. , Han J , Wang Y, Meng Q, Li G, Huang F, Wu S , Fei Y, Zhou F, Fu J., Eur J Med Chem. May 26, 2017; 132 81-89.
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling. , Han W, Lee H , Han JK ., Sci Rep. February 15, 2017; 7 42590.
Tbx2 regulates anterior neural specification by repressing FGF signaling pathway. , Cho GS, Park DS, Choi SC, Han JK ., Dev Biol. January 15, 2017; 421 (2): 183-193.
PLD1 regulates Xenopus convergent extension movements by mediating Frizzled7 endocytosis for Wnt/PCP signal activation. , Lee H , Lee SJ, Kim GH , Yeo I, Han JK ., Dev Biol. March 1, 2016; 411 (1): 38-49.
WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. , Wang D, Zhang Y , Han J , Pan S, Xu N, Feng X, Zhuang Z, Caroti C, Zhuang J, Hoover RS, Gu D, Zeng Q, Cai H., Nephron. January 1, 2016; 133 (4): 287-95.
Gabapentin inhibits the activity of the rat excitatory glutamate transporter 3 expressed in Xenopus oocytes. , Gil YS, Kim JH , Kim CH, Han JI , Zuo Z, Baik HJ., Eur J Pharmacol. September 5, 2015; 762 112-7.
Cellular analysis of cleavage-stage chick embryos reveals hidden conservation in vertebrate early development. , Nagai H, Sezaki M, Kakiguchi K, Nakaya Y, Lee HC , Ladher R, Sasanami T, Han JY , Yonemura S, Sheng G., Development. April 1, 2015; 142 (7): 1279-86.
Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling. , Sheng R, Kim H , Lee H , Xin Y, Chen Y , Tian W, Cui Y, Choi JC, Doh J, Han JK , Cho W., Nat Commun. July 15, 2014; 5 4393.
Role of Sp5 as an essential early regulator of neural crest specification in xenopus. , Park DS, Seo JH, Hong M, Bang W, Han JK , Choi SC., Dev Dyn. December 1, 2013; 242 (12): 1382-94.
β- Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements. , Kim GH , Park EC , Lee H , Na HJ, Choi SC, Han JK ., Biochem Biophys Res Commun. May 31, 2013; 435 (2): 182-7.
BMP signal attenuates FGF pathway in anteroposterior neural patterning. , Cho GS, Choi SC, Han JK ., Biochem Biophys Res Commun. May 10, 2013; 434 (3): 509-15.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. , Kim WT, Kim H , Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK , Jho EH ., EMBO J. August 15, 2012; 31 (16): 3384-97.
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. , Gu SQ, Bakthavachalu B, Han J , Patil DP, Otsuka Y, Guda C, Schoenberg DR ., RNA. June 1, 2012; 18 (6): 1186-96.
Effects of clonidine on the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes. , Woo JH, Han JI , Baik HJ, Lee H ., Korean J Anesthesiol. March 1, 2012; 62 (3): 266-71.
Wnt/planar cell polarity signaling in the regulation of convergent extension movements during Xenopus gastrulation. , Kim GH , Park EC , Han JK ., Methods Mol Biol. January 1, 2012; 839 79-89.
Analysis of the expression of microtubule plus-end tracking proteins (+TIPs) during Xenopus laevis embryogenesis. , Park EC , Lee H , Hong Y, Kim MJ , Lee ZW, Kim SI, Kim S, Kim GH , Han JK ., Gene Expr Patterns. January 1, 2012; 12 (5-6): 204-12.
Rab3d is required for Xenopus anterior neurulation by regulating Noggin secretion. , Kim H , Han JK ., Dev Dyn. June 1, 2011; 240 (6): 1430-9.
Isolation and Expression Profile of the Ca-Activated Chloride Channel-like Membrane Protein 6 Gene in Xenopus laevis. , Lee RM, Ryu RH, Jeong SW, Oh SJ, Huang H, Han JS , Lee CH , Lee CJ , Jan LY, Jeong SM., Lab Anim Res. June 1, 2011; 27 (2): 109-16.
The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements. , Park EC , Cho GS, Kim GH , Choi SC, Han JK ., Dev Biol. February 15, 2011; 350 (2): 441-50.
Role of Tbx2 in defining the territory of the pronephric nephron. , Cho GS, Choi SC, Park EC , Han JK ., Development. February 1, 2011; 138 (3): 465-74.
Top-down analysis of recombinant histone H3 and its methylated analogs by ESI/FT-ICR mass spectrometry. , Han J , Borchers CH., Proteomics. October 1, 2010; 10 (20): 3621-30.
Molecular coevolution of kisspeptins and their receptors from fish to mammals. , Um HN, Han JM , Hwang JI, Hong SI, Vaudry H, Seong JY., Ann N Y Acad Sci. July 1, 2010; 1200 67-74.
Molecular cloning and characterization of the germ cell-related nuclear orphan receptor in chickens. , Lee SI, Kim JK , Park HJ, Jang HJ, Lee HC , Min T, Song G, Han JY ., Mol Reprod Dev. March 1, 2010; 77 (3): 273-84.