Timothy J. Mitchison - Publications

Publications (102)

XB-PERS-2331

Publications By Timothy J. Mitchison

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Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands., Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW., Dev Biol. January 1, 2023; 493 67-79.
Spatial variation of microtubule depolymerization in large asters., Ishihara K, Decker F, Caldas P, Pelletier JF, Loose M, Brugués J, Mitchison TJ., Mol Biol Cell. April 19, 2021; 32 (9): 869-879.
Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm., Pelletier JF, Field CM, Fürthauer S, Sonnett M, Mitchison TJ., Elife. December 7, 2020; 9
Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density., Geisterfer ZM, Zhu DY, Mitchison TJ, Oakey J, Gatlin JC., Curr Biol. August 3, 2020; 30 (15): 3016-3023.e3.
Toward synthetic cells., Mitchison TJ, Field CM., Science. November 1, 2019; 366 (6465): 569-570.
Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs., Field CM, Pelletier JF, Mitchison TJ., Curr Biol. June 17, 2019; 29 (12): 1999-2008.e4.
Colloid osmotic parameterization and measurement of subcellular crowding., Mitchison TJ., Mol Biol Cell. January 15, 2019; 30 (2): 173-180.
Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos., Nguyen T, Mitchison TJ, Wühr M., Methods Mol Biol. January 1, 2019; 1920 17-32.
Assembly of Spindles and Asters in Xenopus Egg Extracts., Field CM, Mitchison TJ., Cold Spring Harb Protoc. June 1, 2018; 2018 (6):
Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters., Nguyen PA, Field CM, Mitchison TJ., Mol Biol Cell. February 1, 2018; 29 (3): 304-316.
Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin., Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ., Mol Biol Cell. June 1, 2017; 28 (11): 1444-1456.
Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis., Field CM, Pelletier JF, Mitchison TJ., Methods Cell Biol. January 1, 2017; 137 395-435.
Spindle-to-Cortex Communication in Cleaving Frog Eggs., Mitchison TJ, Field CM., Cold Spring Harb Symp Quant Biol. January 1, 2017; 82 165-171.
Physical basis of large microtubule aster growth., Ishihara K, Korolev KS, Mitchison TJ., Elife. November 28, 2016; 5
Amyloid-like Self-Assembly of a Cellular Compartment., Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ., Cell. July 28, 2016; 166 (3): 637-650.
Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts., Groen AC, Mitchison TJ., Methods Mol Biol. January 1, 2016; 1413 35-45.
The Nuclear Proteome of a Vertebrate., Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP., Curr Biol. October 19, 2015; 25 (20): 2663-71.
Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs., Field CM, Groen AC, Nguyen PA, Mitchison TJ., Mol Biol Cell. October 15, 2015; 26 (20): 3628-40.
Size Scaling of Microtubule Assemblies in Early Xenopus Embryos., Mitchison TJ, Ishihara K, Nguyen P, Wühr M., Cold Spring Harb Perspect Biol. August 10, 2015; 7 (10): a019182.
Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins., Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M., Methods Cell Biol. January 1, 2015; 128 223-241.
Microtubule nucleation remote from centrosomes may explain how asters span large cells., Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ., Proc Natl Acad Sci U S A. December 16, 2014; 111 (50): 17715-22.
Spatial organization of cytokinesis signaling reconstituted in a cell-free system., Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ., Science. October 10, 2014; 346 (6206): 244-7.
Electron microscopy of microtubule cytoskeleton assembly in vitro., Coughlin M, Groen AC, Mitchison TJ., Methods Mol Biol. January 1, 2014; 1117 259-71.
Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization., Groen AC, Ngyuen PA, Field CM, Ishihara K, Mitchison TJ., Methods Enzymol. January 1, 2014; 540 417-33.
Xenopus egg cytoplasm with intact actin., Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ., Methods Enzymol. January 1, 2014; 540 399-415.
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts., Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA., J Cell Biol. December 9, 2013; 203 (5): 801-14.
Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol., Mitchison TJ, Nguyen P, Coughlin M, Groen AC., Mol Biol Cell. May 1, 2013; 24 (10): 1559-73.
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2., Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD., Cell. February 14, 2013; 152 (4): 768-77.
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells., Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM., Cytoskeleton (Hoboken). October 1, 2012; 69 (10): 738-50.
Vascular disrupting agent drug classes differ in effects on the cytoskeleton., Kim S, Peshkin L, Mitchison TJ., PLoS One. January 1, 2012; 7 (7): e40177.
Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.
Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos., Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ., J Cell Sci. June 15, 2011; 124 (Pt 12): 2086-95.
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes., Brangwynne CP, Mitchison TJ, Hyman AA., Proc Natl Acad Sci U S A. March 15, 2011; 108 (11): 4334-9.
A model for cleavage plane determination in early amphibian and fish embryos., Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ., Curr Biol. November 23, 2010; 20 (22): 2040-5.
Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover., Kueh HY, Brieher WM, Mitchison TJ., Biophys J. October 6, 2010; 99 (7): 2153-62.
Directly probing the mechanical properties of the spindle and its matrix., Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED., J Cell Biol. February 22, 2010; 188 (4): 481-9.
Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition., Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ., Mol Cell Proteomics. February 1, 2010; 9 (2): 336-50.
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity., Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED., Curr Biol. July 28, 2009; 19 (14): 1210-5.
Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly., Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ., Mol Biol Cell. June 1, 2009; 20 (11): 2766-73.
How does a millimeter-sized cell find its center?, Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ., Cell Cycle. April 15, 2009; 8 (8): 1115-21.
Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules., Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED., Curr Biol. February 24, 2009; 19 (4): 287-96.
Mitosis: new roles for myosin-X and actin at the spindle., Wühr M, Mitchison TJ, Field CM., Curr Biol. October 14, 2008; 18 (19): R912-4.
Evidence for an upper limit to mitotic spindle length., Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ., Curr Biol. August 26, 2008; 18 (16): 1256-61.
A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly., Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ., J Cell Sci. July 15, 2008; 121 (Pt 14): 2293-300.
Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm., Niethammer P, Kueh HY, Mitchison TJ., Curr Biol. April 22, 2008; 18 (8): 586-91.
Slide-and-cluster models for spindle assembly., Burbank KS, Mitchison TJ, Fisher DS., Curr Biol. August 21, 2007; 17 (16): 1373-83.
Nonredundant functions of Kinesin-13s during meiotic spindle assembly., Ohi R, Burbank K, Liu Q, Mitchison TJ., Curr Biol. June 5, 2007; 17 (11): 953-9.
A new method reveals microtubule minus ends throughout the meiotic spindle., Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ., J Cell Biol. November 6, 2006; 175 (3): 369-75.
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules., Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW., Mol Biol Cell. June 1, 2006; 17 (6): 2646-60.
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function., Chang P, Coughlin M, Mitchison TJ., Nat Cell Biol. November 1, 2005; 7 (11): 1133-9.

Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands., Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW., Dev Biol. January 1, 2023; 493 67-79.

Spatial variation of microtubule depolymerization in large asters., Ishihara K, Decker F, Caldas P, Pelletier JF, Loose M, Brugués J, Mitchison TJ., Mol Biol Cell. April 19, 2021; 32 (9): 869-879.

Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm., Pelletier JF, Field CM, Fürthauer S, Sonnett M, Mitchison TJ., Elife. December 7, 2020; 9

Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density., Geisterfer ZM, Zhu DY, Mitchison TJ, Oakey J, Gatlin JC., Curr Biol. August 3, 2020; 30 (15): 3016-3023.e3.

Toward synthetic cells., Mitchison TJ, Field CM., Science. November 1, 2019; 366 (6465): 569-570.

Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs., Field CM, Pelletier JF, Mitchison TJ., Curr Biol. June 17, 2019; 29 (12): 1999-2008.e4.

Colloid osmotic parameterization and measurement of subcellular crowding., Mitchison TJ., Mol Biol Cell. January 15, 2019; 30 (2): 173-180.

Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos., Nguyen T, Mitchison TJ, Wühr M., Methods Mol Biol. January 1, 2019; 1920 17-32.

Assembly of Spindles and Asters in Xenopus Egg Extracts., Field CM, Mitchison TJ., Cold Spring Harb Protoc. June 1, 2018; 2018 (6):

Prc1E and Kif4A control microtubule organization within and between large Xenopus egg asters., Nguyen PA, Field CM, Mitchison TJ., Mol Biol Cell. February 1, 2018; 29 (3): 304-316.

Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin., Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ., Mol Biol Cell. June 1, 2017; 28 (11): 1444-1456.

Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis., Field CM, Pelletier JF, Mitchison TJ., Methods Cell Biol. January 1, 2017; 137 395-435.

Spindle-to-Cortex Communication in Cleaving Frog Eggs., Mitchison TJ, Field CM., Cold Spring Harb Symp Quant Biol. January 1, 2017; 82 165-171.

Physical basis of large microtubule aster growth., Ishihara K, Korolev KS, Mitchison TJ., Elife. November 28, 2016; 5

Amyloid-like Self-Assembly of a Cellular Compartment., Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ., Cell. July 28, 2016; 166 (3): 637-650.

Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts., Groen AC, Mitchison TJ., Methods Mol Biol. January 1, 2016; 1413 35-45.

The Nuclear Proteome of a Vertebrate., Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP., Curr Biol. October 19, 2015; 25 (20): 2663-71.

Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs., Field CM, Groen AC, Nguyen PA, Mitchison TJ., Mol Biol Cell. October 15, 2015; 26 (20): 3628-40.

Size Scaling of Microtubule Assemblies in Early Xenopus Embryos., Mitchison TJ, Ishihara K, Nguyen P, Wühr M., Cold Spring Harb Perspect Biol. August 10, 2015; 7 (10): a019182.

Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins., Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M., Methods Cell Biol. January 1, 2015; 128 223-241.

Microtubule nucleation remote from centrosomes may explain how asters span large cells., Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ., Proc Natl Acad Sci U S A. December 16, 2014; 111 (50): 17715-22.

Spatial organization of cytokinesis signaling reconstituted in a cell-free system., Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ., Science. October 10, 2014; 346 (6206): 244-7.

Electron microscopy of microtubule cytoskeleton assembly in vitro., Coughlin M, Groen AC, Mitchison TJ., Methods Mol Biol. January 1, 2014; 1117 259-71.

Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization., Groen AC, Ngyuen PA, Field CM, Ishihara K, Mitchison TJ., Methods Enzymol. January 1, 2014; 540 417-33.

Xenopus egg cytoplasm with intact actin., Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ., Methods Enzymol. January 1, 2014; 540 399-415.

Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts., Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA., J Cell Biol. December 9, 2013; 203 (5): 801-14.

Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol., Mitchison TJ, Nguyen P, Coughlin M, Groen AC., Mol Biol Cell. May 1, 2013; 24 (10): 1559-73.

Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2., Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD., Cell. February 14, 2013; 152 (4): 768-77.

Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells., Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM., Cytoskeleton (Hoboken). October 1, 2012; 69 (10): 738-50.

Vascular disrupting agent drug classes differ in effects on the cytoskeleton., Kim S, Peshkin L, Mitchison TJ., PLoS One. January 1, 2012; 7 (7): e40177.

Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.

Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos., Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ., J Cell Sci. June 15, 2011; 124 (Pt 12): 2086-95.

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes., Brangwynne CP, Mitchison TJ, Hyman AA., Proc Natl Acad Sci U S A. March 15, 2011; 108 (11): 4334-9.

A model for cleavage plane determination in early amphibian and fish embryos., Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ., Curr Biol. November 23, 2010; 20 (22): 2040-5.

Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover., Kueh HY, Brieher WM, Mitchison TJ., Biophys J. October 6, 2010; 99 (7): 2153-62.

Directly probing the mechanical properties of the spindle and its matrix., Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED., J Cell Biol. February 22, 2010; 188 (4): 481-9.

Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition., Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ., Mol Cell Proteomics. February 1, 2010; 9 (2): 336-50.

Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity., Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED., Curr Biol. July 28, 2009; 19 (14): 1210-5.

Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly., Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ., Mol Biol Cell. June 1, 2009; 20 (11): 2766-73.

How does a millimeter-sized cell find its center?, Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ., Cell Cycle. April 15, 2009; 8 (8): 1115-21.

Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules., Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED., Curr Biol. February 24, 2009; 19 (4): 287-96.

Mitosis: new roles for myosin-X and actin at the spindle., Wühr M, Mitchison TJ, Field CM., Curr Biol. October 14, 2008; 18 (19): R912-4.

Evidence for an upper limit to mitotic spindle length., Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ., Curr Biol. August 26, 2008; 18 (16): 1256-61.

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly., Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ., J Cell Sci. July 15, 2008; 121 (Pt 14): 2293-300.

Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm., Niethammer P, Kueh HY, Mitchison TJ., Curr Biol. April 22, 2008; 18 (8): 586-91.

Slide-and-cluster models for spindle assembly., Burbank KS, Mitchison TJ, Fisher DS., Curr Biol. August 21, 2007; 17 (16): 1373-83.

Nonredundant functions of Kinesin-13s during meiotic spindle assembly., Ohi R, Burbank K, Liu Q, Mitchison TJ., Curr Biol. June 5, 2007; 17 (11): 953-9.

A new method reveals microtubule minus ends throughout the meiotic spindle., Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ., J Cell Biol. November 6, 2006; 175 (3): 369-75.

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules., Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW., Mol Biol Cell. June 1, 2006; 17 (6): 2646-60.

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function., Chang P, Coughlin M, Mitchison TJ., Nat Cell Biol. November 1, 2005; 7 (11): 1133-9.

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