Tim Hunt - Publications

Publications (55)

XB-PERS-2439

Publications By Tim Hunt

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On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis., Hunt T., Adv Biol Regul. May 1, 2013; 53 (2): 173-8.
Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis., Mochida S, Maslen SL, Skehel M, Hunt T., Science. December 17, 2010; 330 (6011): 1670-3.
Identification of substrates for cyclin dependent kinases., Errico A, Deshmukh K, Tanaka Y, Pozniakovsky A, Hunt T., Adv Enzyme Regul. January 1, 2010; 50 (1): 375-99.
Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion., Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V., EMBO J. December 2, 2009; 28 (23): 3681-92.
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts., Mochida S, Ikeo S, Gannon J, Hunt T., EMBO J. September 16, 2009; 28 (18): 2777-85.
Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation., Ruiz EJ, Hunt T, Nebreda AR., Mol Cell. October 24, 2008; 32 (2): 210-20.
Calcineurin is required to release Xenopus egg extracts from meiotic M phase., Mochida S, Hunt T., Nature. September 20, 2007; 449 (7160): 336-40.
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts., Errico A, Costanzo V, Hunt T., Proc Natl Acad Sci U S A. September 18, 2007; 104 (38): 14929-34.
The crystal structure of human cyclin B., Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R., Cell Cycle. June 1, 2007; 6 (11): 1342-9.
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase., Casaletto JB, Nutt LK, Wu Q, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S., J Cell Biol. April 11, 2005; 169 (1): 61-71.
Characterization of a new family of cyclin-dependent kinase activators., Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR., Biochem J. March 1, 2005; 386 (Pt 2): 349-55.
Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Dorée., Prigent C, Hunt T., Biol Cell. April 1, 2004; 96 (3): 181-5.
Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts., Yamano H, Gannon J, Mahbubani H, Hunt T., Mol Cell. January 16, 2004; 13 (1): 137-47.
Unmasking the S-phase-promoting potential of cyclin B1., Moore JD, Kirk JA, Hunt T., Science. May 9, 2003; 300 (5621): 987-90.
Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis., Moore JD, Kornbluth S, Hunt T., Mol Biol Cell. December 1, 2002; 13 (12): 4388-400.
New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation., Hochegger H, Klotzbücher A, Kirk J, Howell M, le Guellec K, Fletcher K, Duncan T, Sohail M, Hunt T., Development. October 1, 2001; 128 (19): 3795-807.
Hox D3 expression in normal and impaired wound healing., Uyeno LA, Newman-Keagle JA, Cheung I, Hunt TK, Young DM, Boudreau N., J Surg Res. September 1, 2001; 100 (1): 46-56.
Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo., Sohail M, Hochegger H, Klotzbücher A, Guellec RL, Hunt T, Southern EM., Nucleic Acids Res. May 15, 2001; 29 (10): 2041-51.
The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases., Yamano H, Kitamura K, Kominami K, Lehmann A, Katayama S, Hunt T, Toda T., Mol Cell. December 1, 2000; 6 (6): 1377-87.
Identification of XDRP1; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation., Funakoshi M, Geley S, Hunt T, Nishimoto T, Kobayashi H., EMBO J. September 15, 1999; 18 (18): 5009-18.
The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p., Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B., J Biol Chem. December 4, 1998; 273 (49): 32421-9.
Fission yeast Cut2 required for anaphase has two destruction boxes., Funabiki H, Yamano H, Nagao K, Tanaka H, Yasuda H, Hunt T, Yanagida M., EMBO J. October 1, 1997; 16 (19): 5977-87.
Xenopus cyclin A1 can associate with Cdc28 in budding yeast, causing cell-cycle arrest with an abnormal distribution of nuclear DNA., Funakoshi M, Sikder H, Ebihara H, Irie K, Sugimoto K, Matsumoto K, Hunt T, Nishimoto T, Kobayashi H., Genes Cells. May 1, 1997; 2 (5): 329-43.
The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe., Yamano H, Gannon J, Hunt T., EMBO J. October 1, 1996; 15 (19): 5268-79.
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts., Strausfeld UP, Howell M, Descombes P, Chevalier S, Rempel RE, Adamczewski J, Maller JL, Hunt T, Blow JJ., J Cell Sci. June 1, 1996; 109 ( Pt 6) 1555-63.
The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity., Goodger NM, Gannon J, Hunt T, Morgan PR., J Pathol. April 1, 1996; 178 (4): 422-8.
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes., Nebreda AR, Gannon JV, Hunt T., EMBO J. November 15, 1995; 14 (22): 5597-607.
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation., Howe JA, Howell M, Hunt T, Newport JW., Genes Dev. May 15, 1995; 9 (10): 1164-76.
Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle., Kobayashi H, Stewart E, Poon RY, Hunt T., J Biol Chem. November 18, 1994; 269 (46): 29153-60.
Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15., Poon RY, Yamashita K, Howell M, Ershler MA, Belyavsky A, Hunt T., J Cell Sci. October 1, 1994; 107 ( Pt 10) 2789-99.
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases., Strausfeld UP, Howell M, Rempel R, Maller JL, Hunt T, Blow JJ., Curr Biol. October 1, 1994; 4 (10): 876-83.
Similarities between somatic cells overexpressing the mos oncogene and oocytes during meiotic interphase., Fukasawa K, Murakami MS, Blair DG, Kuriyama R, Hunt T, Fischinger P, Vande Woude GF., Cell Growth Differ. October 1, 1994; 5 (10): 1093-103.
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins., Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR., Cell. September 23, 1994; 78 (6): 1027-37.
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation., Sheets MD, Fox CA, Hunt T, Vande Woude G, Wickens M., Genes Dev. April 15, 1994; 8 (8): 926-38.
Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2., Stewart E, Kobayashi H, Harrison D, Hunt T., EMBO J. February 1, 1994; 13 (3): 584-94.
The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo., Nebreda AR, Hill C, Gomez N, Cohen P, Hunt T., FEBS Lett. October 25, 1993; 333 (1-2): 183-7.
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2., Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J., EMBO J. August 1, 1993; 12 (8): 3123-32.
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs., Nebreda AR, Hunt T., EMBO J. May 1, 1993; 12 (5): 1979-86.
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits., Kobayashi H, Stewart E, Poon R, Adamczewski JP, Gannon J, Hunt T., Mol Biol Cell. November 1, 1992; 3 (11): 1279-94.
Plasmid cDNA-directed protein synthesis in a coupled eukaryotic in vitro transcription-translation system., Craig D, Howell MT, Gibbs CL, Hunt T, Jackson RJ., Nucleic Acids Res. October 11, 1992; 20 (19): 4987-95.
Cell cycle arrest and c-mos., Hunt T., Nature. February 13, 1992; 355 (6361): 587-8.
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis., Kobayashi H, Minshull J, Ford C, Golsteyn R, Poon R, Hunt T., J Cell Biol. August 1, 1991; 114 (4): 755-65.
Xenopus oocyte maturation does not require new cyclin synthesis., Minshull J, Murray A, Colman A, Hunt T., J Cell Biol. August 1, 1991; 114 (4): 767-72.
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs., Watanabe N, Hunt T, Ikawa Y, Sagata N., Nature. July 18, 1991; 352 (6332): 247-8.
Cyclins and their partners during Xenopus oocyte maturation., Kobayashi H, Golsteyn R, Poon R, Stewart E, Gannon J, Minshull J, Smith R, Hunt T., Cold Spring Harb Symp Quant Biol. January 1, 1991; 56 437-47.
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle., Minshull J, Golsteyn R, Hill CS, Hunt T., EMBO J. September 1, 1990; 9 (9): 2865-75.
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase., Félix MA, Labbé JC, Dorée M, Hunt T, Karsenti E., Nature. July 26, 1990; 346 (6282): 379-82.
Cyclin is a component of maturation-promoting factor from Xenopus., Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller JL., Cell. February 9, 1990; 60 (3): 487-94.
Embryology. Under arrest in the cell cycle., Hunt T., Nature. November 30, 1989; 342 (6249): 483-4.
A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity., Felix MA, Pines J, Hunt T, Karsenti E., EMBO J. October 1, 1989; 8 (10): 3059-69.

On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis., Hunt T., Adv Biol Regul. May 1, 2013; 53 (2): 173-8.

Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis., Mochida S, Maslen SL, Skehel M, Hunt T., Science. December 17, 2010; 330 (6011): 1670-3.

Identification of substrates for cyclin dependent kinases., Errico A, Deshmukh K, Tanaka Y, Pozniakovsky A, Hunt T., Adv Enzyme Regul. January 1, 2010; 50 (1): 375-99.

Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion., Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V., EMBO J. December 2, 2009; 28 (23): 3681-92.

Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts., Mochida S, Ikeo S, Gannon J, Hunt T., EMBO J. September 16, 2009; 28 (18): 2777-85.

Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation., Ruiz EJ, Hunt T, Nebreda AR., Mol Cell. October 24, 2008; 32 (2): 210-20.

Calcineurin is required to release Xenopus egg extracts from meiotic M phase., Mochida S, Hunt T., Nature. September 20, 2007; 449 (7160): 336-40.

Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts., Errico A, Costanzo V, Hunt T., Proc Natl Acad Sci U S A. September 18, 2007; 104 (38): 14929-34.

The crystal structure of human cyclin B., Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R., Cell Cycle. June 1, 2007; 6 (11): 1342-9.

Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase., Casaletto JB, Nutt LK, Wu Q, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S., J Cell Biol. April 11, 2005; 169 (1): 61-71.

Characterization of a new family of cyclin-dependent kinase activators., Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR., Biochem J. March 1, 2005; 386 (Pt 2): 349-55.

Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Dorée., Prigent C, Hunt T., Biol Cell. April 1, 2004; 96 (3): 181-5.

Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts., Yamano H, Gannon J, Mahbubani H, Hunt T., Mol Cell. January 16, 2004; 13 (1): 137-47.

Unmasking the S-phase-promoting potential of cyclin B1., Moore JD, Kirk JA, Hunt T., Science. May 9, 2003; 300 (5621): 987-90.

Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis., Moore JD, Kornbluth S, Hunt T., Mol Biol Cell. December 1, 2002; 13 (12): 4388-400.

New B-type cyclin synthesis is required between meiosis I and II during Xenopus oocyte maturation., Hochegger H, Klotzbücher A, Kirk J, Howell M, le Guellec K, Fletcher K, Duncan T, Sohail M, Hunt T., Development. October 1, 2001; 128 (19): 3795-807.

Hox D3 expression in normal and impaired wound healing., Uyeno LA, Newman-Keagle JA, Cheung I, Hunt TK, Young DM, Boudreau N., J Surg Res. September 1, 2001; 100 (1): 46-56.

Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo., Sohail M, Hochegger H, Klotzbücher A, Guellec RL, Hunt T, Southern EM., Nucleic Acids Res. May 15, 2001; 29 (10): 2041-51.

The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases., Yamano H, Kitamura K, Kominami K, Lehmann A, Katayama S, Hunt T, Toda T., Mol Cell. December 1, 2000; 6 (6): 1377-87.

Identification of XDRP1; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation., Funakoshi M, Geley S, Hunt T, Nishimoto T, Kobayashi H., EMBO J. September 15, 1999; 18 (18): 5009-18.

The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p., Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B., J Biol Chem. December 4, 1998; 273 (49): 32421-9.

Fission yeast Cut2 required for anaphase has two destruction boxes., Funabiki H, Yamano H, Nagao K, Tanaka H, Yasuda H, Hunt T, Yanagida M., EMBO J. October 1, 1997; 16 (19): 5977-87.

Xenopus cyclin A1 can associate with Cdc28 in budding yeast, causing cell-cycle arrest with an abnormal distribution of nuclear DNA., Funakoshi M, Sikder H, Ebihara H, Irie K, Sugimoto K, Matsumoto K, Hunt T, Nishimoto T, Kobayashi H., Genes Cells. May 1, 1997; 2 (5): 329-43.

The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe., Yamano H, Gannon J, Hunt T., EMBO J. October 1, 1996; 15 (19): 5268-79.

Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts., Strausfeld UP, Howell M, Descombes P, Chevalier S, Rempel RE, Adamczewski J, Maller JL, Hunt T, Blow JJ., J Cell Sci. June 1, 1996; 109 ( Pt 6) 1555-63.

The localization of p34cdc2 in the cells of normal, hyperplastic, and malignant epithelial and lymphoid tissues of the oral cavity., Goodger NM, Gannon J, Hunt T, Morgan PR., J Pathol. April 1, 1996; 178 (4): 422-8.

Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes., Nebreda AR, Gannon JV, Hunt T., EMBO J. November 15, 1995; 14 (22): 5597-607.

Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation., Howe JA, Howell M, Hunt T, Newport JW., Genes Dev. May 15, 1995; 9 (10): 1164-76.

Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle., Kobayashi H, Stewart E, Poon RY, Hunt T., J Biol Chem. November 18, 1994; 269 (46): 29153-60.

Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15., Poon RY, Yamashita K, Howell M, Ershler MA, Belyavsky A, Hunt T., J Cell Sci. October 1, 1994; 107 ( Pt 10) 2789-99.

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases., Strausfeld UP, Howell M, Rempel R, Maller JL, Hunt T, Blow JJ., Curr Biol. October 1, 1994; 4 (10): 876-83.

Similarities between somatic cells overexpressing the mos oncogene and oocytes during meiotic interphase., Fukasawa K, Murakami MS, Blair DG, Kuriyama R, Hunt T, Fischinger P, Vande Woude GF., Cell Growth Differ. October 1, 1994; 5 (10): 1093-103.

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins., Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR., Cell. September 23, 1994; 78 (6): 1027-37.

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation., Sheets MD, Fox CA, Hunt T, Vande Woude G, Wickens M., Genes Dev. April 15, 1994; 8 (8): 926-38.

Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2., Stewart E, Kobayashi H, Harrison D, Hunt T., EMBO J. February 1, 1994; 13 (3): 584-94.

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo., Nebreda AR, Hill C, Gomez N, Cohen P, Hunt T., FEBS Lett. October 25, 1993; 333 (1-2): 183-7.

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2., Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J., EMBO J. August 1, 1993; 12 (8): 3123-32.

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs., Nebreda AR, Hunt T., EMBO J. May 1, 1993; 12 (5): 1979-86.

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits., Kobayashi H, Stewart E, Poon R, Adamczewski JP, Gannon J, Hunt T., Mol Biol Cell. November 1, 1992; 3 (11): 1279-94.

Plasmid cDNA-directed protein synthesis in a coupled eukaryotic in vitro transcription-translation system., Craig D, Howell MT, Gibbs CL, Hunt T, Jackson RJ., Nucleic Acids Res. October 11, 1992; 20 (19): 4987-95.

Cell cycle arrest and c-mos., Hunt T., Nature. February 13, 1992; 355 (6361): 587-8.

On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis., Kobayashi H, Minshull J, Ford C, Golsteyn R, Poon R, Hunt T., J Cell Biol. August 1, 1991; 114 (4): 755-65.

Xenopus oocyte maturation does not require new cyclin synthesis., Minshull J, Murray A, Colman A, Hunt T., J Cell Biol. August 1, 1991; 114 (4): 767-72.

Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs., Watanabe N, Hunt T, Ikawa Y, Sagata N., Nature. July 18, 1991; 352 (6332): 247-8.

Cyclins and their partners during Xenopus oocyte maturation., Kobayashi H, Golsteyn R, Poon R, Stewart E, Gannon J, Minshull J, Smith R, Hunt T., Cold Spring Harb Symp Quant Biol. January 1, 1991; 56 437-47.

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle., Minshull J, Golsteyn R, Hill CS, Hunt T., EMBO J. September 1, 1990; 9 (9): 2865-75.

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase., Félix MA, Labbé JC, Dorée M, Hunt T, Karsenti E., Nature. July 26, 1990; 346 (6282): 379-82.

Cyclin is a component of maturation-promoting factor from Xenopus., Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller JL., Cell. February 9, 1990; 60 (3): 487-94.

Embryology. Under arrest in the cell cycle., Hunt T., Nature. November 30, 1989; 342 (6249): 483-4.

A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity., Felix MA, Pines J, Hunt T, Karsenti E., EMBO J. October 1, 1989; 8 (10): 3059-69.

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