Fred J Sigworth - Publications

Publications (29)

XB-PERS-3645

Publications By Fred J Sigworth

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State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels., Miranda P, Contreras JE, Plested AJ, Sigworth FJ, Holmgren M, Giraldez T., Proc Natl Acad Sci U S A. March 26, 2013; 110 (13): 5217-22.
Improved hidden Markov models for molecular motors, part 2: extensions and application to experimental data., Syed S, Müllner FE, Selvin PR, Sigworth FJ., Biophys J. December 1, 2010; 99 (11): 3696-703.
Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon., Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM., Am J Physiol Cell Physiol. August 1, 2010; 299 (2): C251-63.
The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels., Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK., J Neurosci. April 29, 2009; 29 (17): 5654-65.
Pharmacological activation and inhibition of Slack (Slo2.2) channels., Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK., Neuropharmacology. September 1, 2006; 51 (4): 896-906.
Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism., Zhang P, Sigworth FJ, Canessa CM., J Gen Physiol. February 1, 2006; 127 (2): 109-17.
An air-molding technique for fabricating PDMS planar patch-clamp electrodes., Klemic KG, Klemic JF, Sigworth FJ., Pflugers Arch. March 1, 2005; 449 (6): 564-72.
Can Shaker potassium channels be locked in the deactivated state?, Yang Y, Yan Y, Sigworth FJ., J Gen Physiol. August 1, 2004; 124 (2): 163-71.
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP., Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK., J Neurosci. December 17, 2003; 23 (37): 11681-91.
Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells., Klemic KG, Klemic JF, Reed MA, Sigworth FJ., Biosens Bioelectron. June 1, 2002; 17 (6-7): 597-604.
Hidden Markov model analysis of intermediate gating steps associated with the pore gate of shaker potassium channels., Zheng J, Vankataramanan L, Sigworth FJ., J Gen Physiol. November 1, 2001; 118 (5): 547-64.
Electrostatics and the gating pore of Shaker potassium channels., Islas LD, Sigworth FJ., J Gen Physiol. January 1, 2001; 117 (1): 69-89.
Voltage sensitivity and gating charge in Shaker and Shab family potassium channels., Islas LD, Sigworth FJ., J Gen Physiol. November 1, 1999; 114 (5): 723-42.
Two-microelectrode voltage clamp of Xenopus oocytes: voltage errors and compensation for local current flow., Baumgartner W, Islas L, Sigworth FJ., Biophys J. October 1, 1999; 77 (4): 1980-91.
Single-channel properties of IKs potassium channels., Yang Y, Sigworth FJ., J Gen Physiol. December 1, 1998; 112 (6): 665-78.
Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels., Zheng J, Sigworth FJ., J Gen Physiol. October 1, 1998; 112 (4): 457-74.
Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 313-42.
Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 295-311.
Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 271-94.
Selectivity changes during activation of mutant Shaker potassium channels., Zheng J, Sigworth FJ., J Gen Physiol. August 1, 1997; 110 (2): 101-17.
How does the W434F mutation block current in Shaker potassium channels?, Yang Y, Yan Y, Sigworth FJ., J Gen Physiol. June 1, 1997; 109 (6): 779-89.
Enhanced closed-state inactivation in a mutant Shaker K+ channel., Ayer RK, Sigworth FJ., J Membr Biol. June 1, 1997; 157 (3): 215-30.
Role of the S3-S4 linker in Shaker potassium channel activation., Mathur R, Zheng J, Yan Y, Sigworth FJ., J Gen Physiol. February 1, 1997; 109 (2): 191-9.
Functional expression and purification of a homomeric human alpha 1 glycine receptor in baculovirus-infected insect cells., Cascio M, Schoppa NE, Grodzicki RL, Sigworth FJ, Fox RO., J Biol Chem. October 15, 1993; 268 (29): 22135-42.
Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly., McCormack K, Lin L, Sigworth FJ., Biophys J. October 1, 1993; 65 (4): 1740-8.
Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels., McCormack K, Lin L, Iverson LE, Tanouye MA, Sigworth FJ., Biophys J. November 1, 1992; 63 (5): 1406-11.
Ion channels. Analysis of nonstationary single-channel currents., Sigworth FJ, Zhou J., Methods Enzymol. January 1, 1992; 207 746-62.
Multiple gating modes and the effect of modulating factors on the microI sodium channel., Zhou JY, Potts JF, Trimmer JS, Agnew WS, Sigworth FJ., Neuron. November 1, 1991; 7 (5): 775-85.
Primary structure and functional expression of a mammalian skeletal muscle sodium channel., Trimmer JS, Cooperman SS, Tomiko SA, Zhou JY, Crean SM, Boyle MB, Kallen RG, Sheng ZH, Barchi RL, Sigworth FJ., Neuron. July 1, 1989; 3 (1): 33-49.

State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels., Miranda P, Contreras JE, Plested AJ, Sigworth FJ, Holmgren M, Giraldez T., Proc Natl Acad Sci U S A. March 26, 2013; 110 (13): 5217-22.

Improved hidden Markov models for molecular motors, part 2: extensions and application to experimental data., Syed S, Müllner FE, Selvin PR, Sigworth FJ., Biophys J. December 1, 2010; 99 (11): 3696-703.

Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon., Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM., Am J Physiol Cell Physiol. August 1, 2010; 299 (2): C251-63.

The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels., Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK., J Neurosci. April 29, 2009; 29 (17): 5654-65.

Pharmacological activation and inhibition of Slack (Slo2.2) channels., Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK., Neuropharmacology. September 1, 2006; 51 (4): 896-906.

Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism., Zhang P, Sigworth FJ, Canessa CM., J Gen Physiol. February 1, 2006; 127 (2): 109-17.

An air-molding technique for fabricating PDMS planar patch-clamp electrodes., Klemic KG, Klemic JF, Sigworth FJ., Pflugers Arch. March 1, 2005; 449 (6): 564-72.

Can Shaker potassium channels be locked in the deactivated state?, Yang Y, Yan Y, Sigworth FJ., J Gen Physiol. August 1, 2004; 124 (2): 163-71.

Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP., Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK., J Neurosci. December 17, 2003; 23 (37): 11681-91.

Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells., Klemic KG, Klemic JF, Reed MA, Sigworth FJ., Biosens Bioelectron. June 1, 2002; 17 (6-7): 597-604.

Hidden Markov model analysis of intermediate gating steps associated with the pore gate of shaker potassium channels., Zheng J, Vankataramanan L, Sigworth FJ., J Gen Physiol. November 1, 2001; 118 (5): 547-64.

Electrostatics and the gating pore of Shaker potassium channels., Islas LD, Sigworth FJ., J Gen Physiol. January 1, 2001; 117 (1): 69-89.

Voltage sensitivity and gating charge in Shaker and Shab family potassium channels., Islas LD, Sigworth FJ., J Gen Physiol. November 1, 1999; 114 (5): 723-42.

Two-microelectrode voltage clamp of Xenopus oocytes: voltage errors and compensation for local current flow., Baumgartner W, Islas L, Sigworth FJ., Biophys J. October 1, 1999; 77 (4): 1980-91.

Single-channel properties of IKs potassium channels., Yang Y, Sigworth FJ., J Gen Physiol. December 1, 1998; 112 (6): 665-78.

Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels., Zheng J, Sigworth FJ., J Gen Physiol. October 1, 1998; 112 (4): 457-74.

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 313-42.

Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 295-311.

Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions., Schoppa NE, Sigworth FJ., J Gen Physiol. February 1, 1998; 111 (2): 271-94.

Selectivity changes during activation of mutant Shaker potassium channels., Zheng J, Sigworth FJ., J Gen Physiol. August 1, 1997; 110 (2): 101-17.

How does the W434F mutation block current in Shaker potassium channels?, Yang Y, Yan Y, Sigworth FJ., J Gen Physiol. June 1, 1997; 109 (6): 779-89.

Enhanced closed-state inactivation in a mutant Shaker K+ channel., Ayer RK, Sigworth FJ., J Membr Biol. June 1, 1997; 157 (3): 215-30.

Role of the S3-S4 linker in Shaker potassium channel activation., Mathur R, Zheng J, Yan Y, Sigworth FJ., J Gen Physiol. February 1, 1997; 109 (2): 191-9.

Functional expression and purification of a homomeric human alpha 1 glycine receptor in baculovirus-infected insect cells., Cascio M, Schoppa NE, Grodzicki RL, Sigworth FJ, Fox RO., J Biol Chem. October 15, 1993; 268 (29): 22135-42.

Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly., McCormack K, Lin L, Sigworth FJ., Biophys J. October 1, 1993; 65 (4): 1740-8.

Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels., McCormack K, Lin L, Iverson LE, Tanouye MA, Sigworth FJ., Biophys J. November 1, 1992; 63 (5): 1406-11.

Ion channels. Analysis of nonstationary single-channel currents., Sigworth FJ, Zhou J., Methods Enzymol. January 1, 1992; 207 746-62.

Multiple gating modes and the effect of modulating factors on the microI sodium channel., Zhou JY, Potts JF, Trimmer JS, Agnew WS, Sigworth FJ., Neuron. November 1, 1991; 7 (5): 775-85.

Primary structure and functional expression of a mammalian skeletal muscle sodium channel., Trimmer JS, Cooperman SS, Tomiko SA, Zhou JY, Crean SM, Boyle MB, Kallen RG, Sheng ZH, Barchi RL, Sigworth FJ., Neuron. July 1, 1989; 3 (1): 33-49.

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