Rowena E Martin - Publications

Publications (25)

XB-PERS-4090

Publications By Rowena E Martin

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Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT., Shafik SH, Richards SN, Corry B, Martin RE., PLoS Biol. May 4, 2022; 20 (5): e3001616.
Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity., Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G., Eur J Med Chem. April 5, 2021; 215 113227.
Identifying the major lactate transporter of Toxoplasma gondii tachyzoites., Zeng JM, Hapuarachchi SV, Shafik SH, Martin RE, Kirk K, van Dooren GG, Lehane AM., Sci Rep. March 24, 2021; 11 (1): 6787.
Inferring a complete genotype-phenotype map from a small number of measured phenotypes., Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ., PLoS Comput Biol. September 29, 2020; 16 (9): e1008243.
The natural function of the malaria parasite's chloroquine resistance transporter., Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE., Nat Commun. August 6, 2020; 11 (1): 3922.
The transportome of the malaria parasite., Martin RE., Biol Rev Camb Philos Soc. April 1, 2020; 95 (2): 305-332.
Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee., Zhang V, Kucharski R, Landers C, Richards SN, Bröer S, Martin RE, Maleszka R., Front Physiol. January 1, 2019; 10 1375.
The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens., Hapuarachchi SV, Cobbold SA, Shafik SH, Dennis AS, McConville MJ, Martin RE, Kirk K, Lehane AM., PLoS Pathog. February 8, 2017; 13 (2): e1006180.
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter., Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE., PLoS Pathog. July 21, 2016; 12 (7): e1005725.
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs., van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE., J Infect Dis. March 1, 2016; 213 (5): 800-10.
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities., Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S., Sci Rep. September 30, 2015; 5 14552.
A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum., Marchetti RV, Lehane AM, Shafik SH, Winterberg M, Martin RE, Kirk K., Nat Commun. March 31, 2015; 6 6721.
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites., Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M., J Biol Chem. December 26, 2014; 289 (52): 36336-51.
1H-NMR metabolite profiles of different strains of Plasmodium falciparum., Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K., Biosci Rep. November 21, 2014; 34 (6): e00150.
Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter., Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): E1759-67.
Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum., Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE., ACS Chem Biol. March 21, 2014; 9 (3): 722-30.
Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT., Deane KJ, Summers RL, Lehane AM, Martin RE, Barrow RA., ACS Med Chem Lett. March 3, 2014; 5 (5): 576-81.
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents., Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S., J Med Chem. December 13, 2012; 55 (23): 10387-404.
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling., Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S., J Med Chem. August 9, 2012; 55 (15): 6948-67.
Saquinavir inhibits the malaria parasite's chloroquine resistance transporter., Martin RE, Butterworth AS, Gardiner DL, Kirk K, McCarthy JS, Skinner-Adams TS., Antimicrob Agents Chemother. May 1, 2012; 56 (5): 2283-9.
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT)., Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ., J Med Chem. October 13, 2011; 54 (19): 6956-68.
A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT., Zishiri VK, Hunter R, Smith PJ, Taylor D, Summers R, Kirk K, Martin RE, Egan TJ., Eur J Med Chem. May 1, 2011; 46 (5): 1729-42.
Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy., Summers RL, Martin RE., Virulence. January 1, 2010; 1 (4): 304-8.
Chloroquine transport via the malaria parasite's chloroquine resistance transporter., Martin RE, Marchetti RV, Cowan AI, Howitt SM, Bröer S, Kirk K., Science. September 25, 2009; 325 (5948): 1680-2.
Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite., Saliba KJ, Martin RE, Bröer A, Henry RI, McCarthy CS, Downie MJ, Allen RJ, Mullin KA, McFadden GI, Bröer S, Kirk K., Nature. October 5, 2006; 443 (7111): 582-5.

Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT., Shafik SH, Richards SN, Corry B, Martin RE., PLoS Biol. May 4, 2022; 20 (5): e3001616.

Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity., Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G., Eur J Med Chem. April 5, 2021; 215 113227.

Identifying the major lactate transporter of Toxoplasma gondii tachyzoites., Zeng JM, Hapuarachchi SV, Shafik SH, Martin RE, Kirk K, van Dooren GG, Lehane AM., Sci Rep. March 24, 2021; 11 (1): 6787.

Inferring a complete genotype-phenotype map from a small number of measured phenotypes., Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ., PLoS Comput Biol. September 29, 2020; 16 (9): e1008243.

The natural function of the malaria parasite's chloroquine resistance transporter., Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE., Nat Commun. August 6, 2020; 11 (1): 3922.

The transportome of the malaria parasite., Martin RE., Biol Rev Camb Philos Soc. April 1, 2020; 95 (2): 305-332.

Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee., Zhang V, Kucharski R, Landers C, Richards SN, Bröer S, Martin RE, Maleszka R., Front Physiol. January 1, 2019; 10 1375.

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens., Hapuarachchi SV, Cobbold SA, Shafik SH, Dennis AS, McConville MJ, Martin RE, Kirk K, Lehane AM., PLoS Pathog. February 8, 2017; 13 (2): e1006180.

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter., Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE., PLoS Pathog. July 21, 2016; 12 (7): e1005725.

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs., van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE., J Infect Dis. March 1, 2016; 213 (5): 800-10.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities., Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, Cooper RA, Krishna S., Sci Rep. September 30, 2015; 5 14552.

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum., Marchetti RV, Lehane AM, Shafik SH, Winterberg M, Martin RE, Kirk K., Nat Commun. March 31, 2015; 6 6721.

Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites., Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M., J Biol Chem. December 26, 2014; 289 (52): 36336-51.

1H-NMR metabolite profiles of different strains of Plasmodium falciparum., Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K., Biosci Rep. November 21, 2014; 34 (6): e00150.

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter., Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): E1759-67.

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum., Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE., ACS Chem Biol. March 21, 2014; 9 (3): 722-30.

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT., Deane KJ, Summers RL, Lehane AM, Martin RE, Barrow RA., ACS Med Chem Lett. March 3, 2014; 5 (5): 576-81.

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents., Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S., J Med Chem. December 13, 2012; 55 (23): 10387-404.

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling., Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S., J Med Chem. August 9, 2012; 55 (15): 6948-67.

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter., Martin RE, Butterworth AS, Gardiner DL, Kirk K, McCarthy JS, Skinner-Adams TS., Antimicrob Agents Chemother. May 1, 2012; 56 (5): 2283-9.

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT)., Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ., J Med Chem. October 13, 2011; 54 (19): 6956-68.

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT., Zishiri VK, Hunter R, Smith PJ, Taylor D, Summers R, Kirk K, Martin RE, Egan TJ., Eur J Med Chem. May 1, 2011; 46 (5): 1729-42.

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy., Summers RL, Martin RE., Virulence. January 1, 2010; 1 (4): 304-8.

Chloroquine transport via the malaria parasite's chloroquine resistance transporter., Martin RE, Marchetti RV, Cowan AI, Howitt SM, Bröer S, Kirk K., Science. September 25, 2009; 325 (5948): 1680-2.

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite., Saliba KJ, Martin RE, Bröer A, Henry RI, McCarthy CS, Downie MJ, Allen RJ, Mullin KA, McFadden GI, Bröer S, Kirk K., Nature. October 5, 2006; 443 (7111): 582-5.

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