Publications By YING XU

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Effects of triclosan adsorption on intestinal toxicity and resistance gene expression in Xenopus tropicalis with different particle sizes of polystyrene., Dai Z, Wang Z, Pan X, Zheng L, Xu Y, Qiao Q., J Environ Sci (China). December 1, 2024; 146 176-185.

In vitro assessment of the bacterial stress response and resistance evolution during multidrug-resistant bacterial invasion of the Xenopus tropicalis intestinal tract under typical stresses., Lin X, Han R, Liang T, Zhang C, Xu Y, Peng H, Zhou X, Huang L., J Hazard Mater. March 15, 2024; 466 133599.

Oxytetracycline and heavy metals promote the migration of resistance genes in the intestinal microbiome by plasmid transfer., Lin X, Zhang C, Han R, Li S, Peng H, Zhou X, Huang L, Xu Y., ISME J. November 1, 2023; 17 (11): 2003-2013.

Toxic effects of long-term dual or single exposure to oxytetracycline and arsenic on Xenopus tropicalis living in duck wastewater., Zhao J, Li X, Xu Y, Li Y, Zheng L, Luan T., J Environ Sci (China). May 1, 2023; 127 431-440.

Intestinal toxicity and resistance gene threat assessment of multidrug-resistant Shigella: A novel biotype pollutant., Zhao J, Zhang C, Xu Y, Li X, Lin X, Lin Z, Luan T., Environ Pollut. January 1, 2023; 316 (Pt 1): 120551.

The Xenopus laevis teratogenesis assay for developmental toxicity of phthalate plasticizers and alternatives., Xu Y, Jang J, Gye MC., Environ Pollut. May 1, 2022; 300 118985.

Effects of Shigella flexneri exposure on development of Xenopus Tropicals embryo and its immune response., Luo W, Dai W, Zhang X, Zheng L, Zhao J, Xie X, Xu Y., J Hazard Mater. April 5, 2022; 427 128153.

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor., Bondarenko V, Wells MM, Chen Q, Tillman TS, Singewald K, Lawless MJ, Caporoso J, Brandon N, Coleman JA, Saxena S, Lindahl E, Xu Y, Tang P., Nat Commun. February 10, 2022; 13 (1): 793.

Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis., Xu Y, Li L, Zheng J, Wang M, Jiang B, Zhai Y, Lu L, Zhang C, Kuang Z, Yang X, Jin LN, Lin G, Zhang C., Endocr Connect. November 15, 2021; 10 (11): 1477-1488.

Pharmacological modulation of dual melanocortin-4 receptor signaling by melanocortin receptor accessory proteins in the Xenopus laevis., Li L, Xu Y, Zheng J, Kuang Z, Zhang C, Li N, Lin G, Zhang C., J Cell Physiol. August 1, 2021; 236 (8): 5980-5993.

Potential reproductive toxicity of multi-walled carbon nanotubes and their chronic exposure effects on the growth and development of Xenopus tropicalis., Zhao J, Luo W, Xu Y, Ling J, Deng L., Sci Total Environ. April 20, 2021; 766 142652.

4-Octylphenol induces developmental abnormalities and interferes the differentiation of neural crest cells in Xenopus laevis embryos., Xu Y, Jang JH, Gye MC., Environ Pollut. April 1, 2021; 274 116560.

Accumulation and toxicity of multi-walled carbon nanotubes in Xenopus tropicalis tadpoles., Zhao J, Xie G, Xu Y, Zheng L, Ling J., Chemosphere. October 1, 2020; 257 127205.

PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits., Yi F, Rouzbeh N, Hansen KB, Xu Y, Fanger CM, Gordon E, Paschetto K, Menniti FS, Volkmann RA., Neuropharmacology. August 15, 2020; 173 107971.

The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus., Piard J, Béreau M, XiangWei W, Wirth T, Amsallem D, Buisson L, Richard P, Liu N, Xu Y, Myers SJ, Traynelis SF, Chelly J, Anheim M, Raynaud M, Maldergem LV, Yuan H., Mov Disord. July 1, 2020; 35 (7): 1224-1232.

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels., Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S., Elife. April 28, 2020; 9

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents., Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA., J Biol Chem. March 13, 2020; 295 (11): 3614-3634.

De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases., Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, Myers SJ, Swanger SA, Wollmuth LP, Petrovski S, Traynelis SF, Yuan H., Hum Mutat. December 1, 2019; 40 (12): 2393-2413.

HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer., Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, Chen W, Wang L, Hou L, Tan W., Am J Transl Res. November 15, 2019; 11 (11): 7035-7048.

OsMTOPVIB is required for meiotic bipolar spindle assembly., Xue Z, Liu C, Shi W, Miao Y, Shen Y, Tang D, Li Y, You A, Xu Y, Chong K, Cheng Z., Proc Natl Acad Sci U S A. August 6, 2019; 116 (32): 15967-15972.

Effects of nonylphenols on embryonic development and metamorphosis of Xenopus laevis: FETAX and amphibian metamorphosis toxicity test (OECD TG231)., Xu Y, Park SJ, Gye MC., Environ Res. July 1, 2019; 174 14-23.

Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells., Bao HL, Liu HS, Xu Y., Nucleic Acids Res. June 4, 2019; 47 (10): 4940-4947.

Structural basis of neurosteroid anesthetic action on GABAA receptors., Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Tang P., Nat Commun. September 28, 2018; 9 (1): 3972.

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites., Wang Y, Yang E, Wells MM, Bondarenko V, Woll K, Carnevale V, Granata D, Klein ML, Eckenhoff RG, Dailey WP, Covarrubias M, Tang P, Xu Y., J Gen Physiol. September 3, 2018; 150 (9): 1317-1331.

Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration., Zhang M, Chen Y, Xu H, Yang L, Yuan F, Li L, Xu Y, Chen Y, Zhang C, Lin G., Dev Cell. August 20, 2018; 46 (4): 397-409.e5.

Developmental toxicity of dibutyl phthalate and citrate ester plasticizers in Xenopus laevis embryos., Xu Y, Gye MC., Chemosphere. August 1, 2018; 204 523-534.

A novel high-affinity inhibitor against the human ATP-sensitive Kir6.2 channel., Ramu Y, Xu Y, Lu Z., J Gen Physiol. July 2, 2018; 150 (7): 969-976.

Investigation of higher-order RNA G-quadruplex structures in vitro and in living cells by 19F NMR spectroscopy., Bao HL, Xu Y., Nat Protoc. April 1, 2018; 13 (4): 652-665.

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2)., Ha J, Xu Y, Kawano T, Hendon T, Baki L, Garai S, Papapetropoulos A, Thakur GA, Plant LD, Logothetis DE., J Biol Chem. March 9, 2018; 293 (10): 3546-3561.

Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction., Shi Y, Li J, Chen C, Xia Y, Li Y, Zhang P, Xu Y, Li T, Zhou W, Song W., Front Mol Neurosci. February 7, 2018; 11 9.

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy., Bao HL, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, Xu Y., Nucleic Acids Res. May 19, 2017; 45 (9): 5501-5511.

Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli., Tillman TS, Alvarez FJ, Reinert NJ, Liu C, Wang D, Xu Y, Xiao K, Zhang P, Tang P., J Biol Chem. August 26, 2016; 291 (35): 18276-82.

Early ketamine exposure results in cardiac enlargement and heart dysfunction in Xenopus embryos., Guo R, Liu G, Du M, Shi Y, Jiang P, Liu X, Liu L, Liu J, Xu Y., BMC Anesthesiol. April 18, 2016; 16 23.

Inhibitory efficacy of bufadienolides on Na+,K+-pump activity versus cell proliferation., Xu Y, Liu X, Schwarz S, Hu L, Guo D, Gu Q, Schwarz W., Biochem Biophys Rep. March 31, 2016; 6 158-164.

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels., Kinde MN, Bu W, Chen Q, Xu Y, Eckenhoff RG, Tang P., Anesthesiology. March 1, 2016; 124 (3): 664-73.

Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels., Xu Y, Furutani S, Ihara M, Ling Y, Yang X, Kai K, Hayashi H, Matsuda K., PLoS One. April 22, 2015; 10 (4): e0122629.

Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain., Wells MM, Tillman TS, Mowrey DD, Sun T, Xu Y, Tang P., J Med Chem. April 9, 2015; 58 (7): 2958-2966.

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A., Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y., Nature. January 29, 2015; 517 (7536): 640-4.

Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid., Ramu Y, Xu Y, Shin HG, Lu Z., Elife. October 14, 2014; 3 e03683.

NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites., Bondarenko V, Mowrey DD, Tillman TS, Seyoum E, Xu Y, Tang P., Biochim Biophys Acta. May 1, 2014; 1838 (5): 1389-95.

Identification, immunolocalization, and immunological characterization of nitric oxide synthase-interacting protein from Clonorchis sinensis., Bian M, Li S, Wang X, Xu Y, Chen W, Zhou C, Chen X, He L, Xu J, Liang C, Wu Z, Huang Y, Li X, Yu X., Parasitol Res. May 1, 2014; 113 (5): 1749-57.

Photoaffinity labeling the propofol binding site in GLIC., Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB., Biochemistry. January 14, 2014; 53 (1): 135-42.

Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase., Combs DJ, Shin HG, Xu Y, Ramu Y, Lu Z., J Gen Physiol. October 1, 2013; 142 (4): 367-80.

Crystal structures of Lgr4 and its complex with R-spondin1., Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling., Nedelcu D, Liu J, Xu Y, Jao C, Salic A., Nat Chem Biol. September 1, 2013; 9 (9): 557-64.

Energetic role of the paddle motif in voltage gating of Shaker K(+) channels., Xu Y, Ramu Y, Shin HG, Yamakaze J, Lu Z., Nat Struct Mol Biol. May 1, 2013; 20 (5): 574-81.

Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins., Sulaiman P, Xu Y, Fina ME, Tummala SR, Ramakrishnan H, Dhingra A, Vardi N., J Biol Chem. March 8, 2013; 288 (10): 7420-9.

Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics., Tillman T, Cheng MH, Chen Q, Tang P, Xu Y., Biochem J. January 1, 2013; 449 (1): 61-8.

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin., Zebisch M, Xu Y, Krastev C, MacDonald BT, Chen M, Gilbert RJ, He X, Jones EY., Nat Commun. January 1, 2013; 4 2787.

Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development., Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG., Cell. December 7, 2012; 151 (6): 1200-13.

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