Malcolm Whitman - Publications

Publications (37)

XB-PERS-710

Publications By Malcolm Whitman

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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome., Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M., Am J Med Genet A. August 1, 2013; 161A (8): 2040-6.
The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo., Ho DM, Yeo CY, Whitman M., Mech Dev. January 1, 2010; 127 (9-12): 485-95.
TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates., Onuma Y, Watanabe A, Aburatani H, Asashima M, Whitman M., Zoolog Sci. July 1, 2008; 25 (7): 706-13.
Identification of a novel pool of extracellular pro-myostatin in skeletal muscle., Anderson SB, Goldberg AL, Whitman M., J Biol Chem. March 14, 2008; 283 (11): 7027-35.
TGF-beta signaling is required for multiple processes during Xenopus tail regeneration., Ho DM, Whitman M., Dev Biol. March 1, 2008; 315 (1): 203-16.
Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo., Ho DM, Chan J, Bayliss P, Whitman M., Dev Biol. July 15, 2006; 295 (2): 730-42.
A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos., Onuma Y, Asashima M, Whitman M., Mech Dev. June 1, 2006; 123 (6): 463-71.
XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning., Onuma Y, Yeo CY, Whitman M., Development. January 1, 2006; 133 (2): 237-50.
Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled., Onuma Y, Takahashi S, Haramoto Y, Tanegashima K, Yokota C, Whitman M, Asashima M., Dev Dyn. December 1, 2005; 234 (4): 900-10.
Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction., Wawersik S, Evola C, Whitman M., Dev Biol. January 15, 2005; 277 (2): 425-42.
New roles for FoxH1 in patterning the early embryo., Kofron M, Puck H, Standley H, Wylie C, Old R, Whitman M, Heasman J., Development. October 1, 2004; 131 (20): 5065-78.
p53 and TGF-beta in development: prelude to tumor suppression?, Whitman M, McKeon F., Cell. May 2, 2003; 113 (3): 275-6.
Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron., Watanabe M, Rebbert ML, Andreazzoli M, Takahashi N, Toyama R, Zimmerman S, Whitman M, Dawid IB., Dev Dyn. December 1, 2002; 225 (4): 448-56.
Endogenous patterns of BMP signaling during early chick development., Faure S, de Santa Barbara P, Roberts DJ, Whitman M., Dev Biol. April 1, 2002; 244 (1): 44-65.
Nodal signaling in early vertebrate embryos: themes and variations., Whitman M., Dev Cell. November 1, 2001; 1 (5): 605-17.
The role of BMP signaling in outgrowth and patterning of the Xenopus tail bud., Beck CW, Whitman M, Slack JM., Dev Biol. October 15, 2001; 238 (2): 303-14.
Fucosylation of Cripto is required for its ability to facilitate nodal signaling., Schiffer SG, Foley S, Kaffashan A, Hronowski X, Zichittella AE, Yeo CY, Miatkowski K, Adkins HB, Damon B, Whitman M, Salomon D, Sanicola M, Williams KP., J Biol Chem. October 12, 2001; 276 (41): 37769-78.
Timing of endogenous activin-like signals and regional specification of the Xenopus embryo., Lee MA, Heasman J, Whitman M., Development. August 1, 2001; 128 (15): 2939-52.
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms., Yeo C, Whitman M., Mol Cell. May 1, 2001; 7 (5): 949-57.
Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2., Shiratori H, Sakuma R, Watanabe M, Hashiguchi H, Mochida K, Sakai Y, Nishino J, Saijoh Y, Whitman M, Hamada H., Mol Cell. January 1, 2001; 7 (1): 137-49.
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development., Faure S, Lee MA, Keller T, ten Dijke P, Whitman M., Development. July 1, 2000; 127 (13): 2917-31.
Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1., Osada SI, Saijoh Y, Frisch A, Yeo CY, Adachi H, Watanabe M, Whitman M, Hamada H, Wright CV., Development. June 1, 2000; 127 (11): 2503-14.
Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2., Saijoh Y, Adachi H, Sakuma R, Yeo CY, Yashiro K, Watanabe M, Hashiguchi H, Mochida K, Ohishi S, Kawabata M, Miyazono K, Whitman M, Hamada H., Mol Cell. January 1, 2000; 5 (1): 35-47.
FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo., Watanabe M, Whitman M., Development. December 1, 1999; 126 (24): 5621-34.
The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis., Yeo CY, Chen X, Whitman M., J Biol Chem. September 10, 1999; 274 (37): 26584-90.
The role of transcription factors involved in TGFbeta superfamily signaling during development., Watanabe M, Whitman M., Cell Mol Biol (Noisy-le-grand). July 1, 1999; 45 (5): 537-43.
A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis., Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M., Mech Dev. December 1, 1998; 79 (1-2): 17-27.
Smad4 and FAST-1 in the assembly of activin-responsive factor., Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M., Nature. September 4, 1997; 389 (6646): 85-9.
Localization of MAP kinase activity in early Xenopus embryos: implications for endogenous FGF signaling., LaBonne C, Whitman M., Dev Biol. March 1, 1997; 183 (1): 9-20.
A transcriptional partner for MAD proteins in TGF-beta signalling., Chen X, Rubock MJ, Whitman M., Nature. October 24, 1996; 383 (6602): 691-6.
Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo., Huang HC, Murtaugh LC, Vize PD, Whitman M., EMBO J. December 1, 1995; 14 (23): 5965-73.
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development., LaBonne C, Burke B, Whitman M., Development. May 1, 1995; 121 (5): 1475-86.
Mesoderm induction by activin requires FGF-mediated intracellular signals., LaBonne C, Whitman M., Development. February 1, 1994; 120 (2): 463-72.
Involvement of p21ras in Xenopus mesoderm induction., Whitman M, Melton DA., Nature. May 21, 1992; 357 (6375): 252-4.
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures., Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA., Cell. November 2, 1990; 63 (3): 485-93.
Signal transduction during mesoderm induction in Xenopus., Whitman M, Melton DA., J Reprod Fertil Suppl. January 1, 1990; 42 249-54.
Induction of mesoderm by a viral oncogene in early Xenopus embryos., Whitman M, Melton DA., Science. May 19, 1989; 244 (4906): 803-6.

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome., Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M., Am J Med Genet A. August 1, 2013; 161A (8): 2040-6.

The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo., Ho DM, Yeo CY, Whitman M., Mech Dev. January 1, 2010; 127 (9-12): 485-95.

TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates., Onuma Y, Watanabe A, Aburatani H, Asashima M, Whitman M., Zoolog Sci. July 1, 2008; 25 (7): 706-13.

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle., Anderson SB, Goldberg AL, Whitman M., J Biol Chem. March 14, 2008; 283 (11): 7027-35.

TGF-beta signaling is required for multiple processes during Xenopus tail regeneration., Ho DM, Whitman M., Dev Biol. March 1, 2008; 315 (1): 203-16.

Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo., Ho DM, Chan J, Bayliss P, Whitman M., Dev Biol. July 15, 2006; 295 (2): 730-42.

A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos., Onuma Y, Asashima M, Whitman M., Mech Dev. June 1, 2006; 123 (6): 463-71.

XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning., Onuma Y, Yeo CY, Whitman M., Development. January 1, 2006; 133 (2): 237-50.

Xnr2 and Xnr5 unprocessed proteins inhibit Wnt signaling upstream of dishevelled., Onuma Y, Takahashi S, Haramoto Y, Tanegashima K, Yokota C, Whitman M, Asashima M., Dev Dyn. December 1, 2005; 234 (4): 900-10.

Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction., Wawersik S, Evola C, Whitman M., Dev Biol. January 15, 2005; 277 (2): 425-42.

New roles for FoxH1 in patterning the early embryo., Kofron M, Puck H, Standley H, Wylie C, Old R, Whitman M, Heasman J., Development. October 1, 2004; 131 (20): 5065-78.

p53 and TGF-beta in development: prelude to tumor suppression?, Whitman M, McKeon F., Cell. May 2, 2003; 113 (3): 275-6.

Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron., Watanabe M, Rebbert ML, Andreazzoli M, Takahashi N, Toyama R, Zimmerman S, Whitman M, Dawid IB., Dev Dyn. December 1, 2002; 225 (4): 448-56.

Endogenous patterns of BMP signaling during early chick development., Faure S, de Santa Barbara P, Roberts DJ, Whitman M., Dev Biol. April 1, 2002; 244 (1): 44-65.

Nodal signaling in early vertebrate embryos: themes and variations., Whitman M., Dev Cell. November 1, 2001; 1 (5): 605-17.

The role of BMP signaling in outgrowth and patterning of the Xenopus tail bud., Beck CW, Whitman M, Slack JM., Dev Biol. October 15, 2001; 238 (2): 303-14.

Fucosylation of Cripto is required for its ability to facilitate nodal signaling., Schiffer SG, Foley S, Kaffashan A, Hronowski X, Zichittella AE, Yeo CY, Miatkowski K, Adkins HB, Damon B, Whitman M, Salomon D, Sanicola M, Williams KP., J Biol Chem. October 12, 2001; 276 (41): 37769-78.

Timing of endogenous activin-like signals and regional specification of the Xenopus embryo., Lee MA, Heasman J, Whitman M., Development. August 1, 2001; 128 (15): 2939-52.

Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms., Yeo C, Whitman M., Mol Cell. May 1, 2001; 7 (5): 949-57.

Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2., Shiratori H, Sakuma R, Watanabe M, Hashiguchi H, Mochida K, Sakai Y, Nishino J, Saijoh Y, Whitman M, Hamada H., Mol Cell. January 1, 2001; 7 (1): 137-49.

Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development., Faure S, Lee MA, Keller T, ten Dijke P, Whitman M., Development. July 1, 2000; 127 (13): 2917-31.

Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1., Osada SI, Saijoh Y, Frisch A, Yeo CY, Adachi H, Watanabe M, Whitman M, Hamada H, Wright CV., Development. June 1, 2000; 127 (11): 2503-14.

Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2., Saijoh Y, Adachi H, Sakuma R, Yeo CY, Yashiro K, Watanabe M, Hashiguchi H, Mochida K, Ohishi S, Kawabata M, Miyazono K, Whitman M, Hamada H., Mol Cell. January 1, 2000; 5 (1): 35-47.

FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo., Watanabe M, Whitman M., Development. December 1, 1999; 126 (24): 5621-34.

The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis., Yeo CY, Chen X, Whitman M., J Biol Chem. September 10, 1999; 274 (37): 26584-90.

The role of transcription factors involved in TGFbeta superfamily signaling during development., Watanabe M, Whitman M., Cell Mol Biol (Noisy-le-grand). July 1, 1999; 45 (5): 537-43.

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis., Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M., Mech Dev. December 1, 1998; 79 (1-2): 17-27.

Smad4 and FAST-1 in the assembly of activin-responsive factor., Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M., Nature. September 4, 1997; 389 (6646): 85-9.

Localization of MAP kinase activity in early Xenopus embryos: implications for endogenous FGF signaling., LaBonne C, Whitman M., Dev Biol. March 1, 1997; 183 (1): 9-20.

A transcriptional partner for MAD proteins in TGF-beta signalling., Chen X, Rubock MJ, Whitman M., Nature. October 24, 1996; 383 (6602): 691-6.

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo., Huang HC, Murtaugh LC, Vize PD, Whitman M., EMBO J. December 1, 1995; 14 (23): 5965-73.

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development., LaBonne C, Burke B, Whitman M., Development. May 1, 1995; 121 (5): 1475-86.

Mesoderm induction by activin requires FGF-mediated intracellular signals., LaBonne C, Whitman M., Development. February 1, 1994; 120 (2): 463-72.

Involvement of p21ras in Xenopus mesoderm induction., Whitman M, Melton DA., Nature. May 21, 1992; 357 (6375): 252-4.

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures., Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA., Cell. November 2, 1990; 63 (3): 485-93.

Signal transduction during mesoderm induction in Xenopus., Whitman M, Melton DA., J Reprod Fertil Suppl. January 1, 1990; 42 249-54.

Induction of mesoderm by a viral oncogene in early Xenopus embryos., Whitman M, Melton DA., Science. May 19, 1989; 244 (4906): 803-6.

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