Monarch Ortholog Phenotypes
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Human (49 sources):
Abnormal cerebral vascular morphology,
Abnormality of mental function,
Abnormality of vision,
Abnormal social behavior,
Agitation,
Alzheimer disease,
Aphasia,
Apraxia,
Ataxia,
Atypical behavior,
Cerebellar hemorrhage,
Cerebral amyloid angiopathy,
Cerebral calcification,
Cerebral cortical atrophy,
Cerebral hemorrhage,
Cerebral ischemia,
Coma,
Confusion,
Decreased circulating GABA concentration,
Dementia,
Deposits immunoreactive to beta-amyloid protein,
Disinhibition,
Dysgraphia,
Dysphagia,
Febrile seizure (within the age range of 3 months to 6 years),
Finger agnosia,
Gait disturbance,
Global developmental delay,
Hallucinations,
Headache,
Intellectual disability,
Language impairment,
Long-tract sign,
Memory impairment,
Mental deterioration,
Migraine,
Myoclonus,
Neurodevelopmental abnormality,
Neurofibrillary tangles,
Oculomotor apraxia,
Paresthesia,
Parkinsonism,
Recurrent cerebral hemorrhage,
Seizure,
Semantic dementia,
Somatic sensory dysfunction,
Spasticity,
Stroke,
Tortuous cerebral arteries
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Mouse (69 sources):
abnormal active avoidance behavior,
abnormal anxiety-related response,
abnormal astrocyte morphology,
abnormal axonal transport,
abnormal axon initial segment morphology,
abnormal brain commissure morphology,
abnormal circadian behavior,
abnormal circulating bilirubin level,
abnormal cued conditioning behavior,
abnormal dentate gyrus morphology,
abnormal excitatory postsynaptic currents,
abnormal grip strength,
abnormal learning/memory/conditioning,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal long term object recognition memory,
abnormal long term potentiation,
abnormal long term spatial reference memory,
abnormal microglial cell morphology,
abnormal motor capabilities/coordination/movement,
abnormal olfactory epithelium morphology,
abnormal olfactory sensory neuron physiology,
abnormal response to new environment,
abnormal spatial learning,
abnormal spatial reference memory,
abnormal spatial working memory,
abnormal startle reflex,
abnormal synapse morphology,
abnormal telencephalon morphology,
amyloid beta deposits,
behavioral arrest,
behavior/neurological phenotype,
clonic seizures,
CNS inflammation,
decreased anterior commissure size,
decreased brain weight,
decreased circulating bilirubin level,
decreased corpus callosum size,
decreased exploration in new environment,
decreased grip strength,
decreased hippocampal commissure size,
decreased locomotor activity,
decreased olfactory sensory neuron number,
decreased startle reflex,
decreased susceptibility to pharmacologically induced seizures,
facial muscle spasm,
growth/size/body region phenotype,
hematoma,
hippocampal neuron degeneration,
homeostasis/metabolism phenotype,
impaired passive avoidance behavior,
impaired swimming,
increased aggression towards mice,
increased anxiety-related response,
increased mean corpuscular hemoglobin,
increased neuron apoptosis,
increased or absent threshold for auditory brainstem response,
increased susceptibility to induced thrombosis,
increased susceptibility to pharmacologically induced seizures,
increased thigmotaxis,
increased variability of skeletal muscle fiber size,
microgliosis,
muscle degeneration,
nervous system phenotype,
neuron degeneration,
no abnormal phenotype detected,
premature death,
preweaning lethality, incomplete penetrance,
reduced long term potentiation
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View all ortholog results at Monarch
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