Monarch Ortholog Phenotypes
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Mouse (45 sources):
abnormal cell adhesion,
abnormal cell migration,
abnormal cerebellar foliation,
abnormal cerebellar lobule formation,
abnormal cerebellum vermis morphology,
abnormal cerebral cortex morphology,
abnormal class switch recombination,
abnormal hindbrain development,
abnormal humoral immune response,
abnormal immunoglobulin heavy chain V(D)J recombination,
abnormal late pro-B cell,
abnormal locomotor activation,
abnormal lymphopoiesis,
absent B-2 B cells,
absent late pro-B cells,
absent mature B cells,
arrested B cell differentiation,
decreased B-1 B cell number,
decreased B-1b cell number,
decreased body size,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased IgG3 level,
decreased immature B cell number,
decreased inferior colliculus size,
decreased mature B cell number,
decreased pre-B cell number,
domed cranium,
hearing/vestibular/ear phenotype,
immune system phenotype,
impaired humoral immune response,
increased anxiety-related response,
increased B-1 B cell number,
increased cardiac muscle contractility,
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased CD8-positive, alpha-beta memory T cell number,
increased macrophage cell number,
increased single-positive T cell number,
lethality at weaning, complete penetrance,
limb grasping,
no abnormal phenotype detected,
postnatal lethality, incomplete penetrance,
premature death,
preweaning lethality, complete penetrance
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