pitx3 Phenotypes

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Phenotypes

Gene Literature (18)

Nucleotides (95)

Interactants (271)

XB-GENEPAGE-486161

Gene Symbol: pitx3 Gene Name: paired like homeodomain 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal determination of left/right symmetry (1 source), abnormal developmental process (1 source), abnormally laterally curved whole organism (1 source), abnormal nodal signaling pathway (1 source), decreased size of the eye primordium (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: pitx3 manipulated (28 sources)
Computed annotations: pitx3 assayed (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + pitx3 MO (22 sources), Xla Wt + pitx3 MO (7 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (13 sources): Blindness, Cataract, Chorea, Intellectual disability, Microcornea, Microphthalmia, Ocular anterior segment dysgenesis, Ocular hypertension, Opacification of the corneal stroma, Peters anomaly, Posterior polar cataract, Reduced tendon reflexes, Spasticity [+]
Mouse (55 sources): abnormal breathing pattern, abnormal coping response, abnormal dorsal striatum morphology, abnormal eye distance/ position, abnormal food intake, abnormal grip strength, abnormal heart rate, abnormal lens development, abnormal locomotor activation, abnormal locomotor behavior, abnormal response to new environment, abnormal sleep behavior, abnormal substantia nigra pars compacta morphology, acoria, aphakia, decreased anxiety-related response, decreased body length, decreased body size, decreased bone mass, decreased chemical nociceptive threshold, decreased circulating amylase level, decreased circulating iron level, decreased dopamine level, decreased dopaminergic neuron number, decreased exploration in new environment, decreased grip strength, decreased IgG3 level, decreased locomotor activity, decreased substantia nigra size, decreased thermal nociceptive threshold, decreased tidal volume, decreased vertical activity, eyelids fail to open, fused cornea and lens, hyperresponsive to tactile stimuli, increased anxiety-related response, increased body temperature, increased bone mineral content, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased circulating alkaline phosphatase level, increased coping response, increased energy expenditure, increased exploration in new environment, increased fasting circulating glucose level, increased granulocyte number, increased grip strength, increased lean body mass, increased neuron apoptosis, increased neuron number, increased pulmonary respiratory rate, loss of dopaminergic neurons, nervous system phenotype, reduced fertility, shortened ST segment [+]
View all ortholog results at Monarch