| Monarch Ortholog Phenotypes
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Human (49 sources):
2-3 toe syndactyly,
Abnormal brain morphology,
Abnormality of the genital system,
Aggressive behavior,
Anxiety,
Arachnodactyly,
Attention deficit hyperactivity disorder,
Bulbous nose,
Butterfly vertebrae,
Clinodactyly,
Delayed speech and language development,
Dental crowding,
Depressed nasal bridge,
Downslanted palpebral fissures,
Epicanthus,
Exaggerated median tongue furrow,
Exotropia,
Facial asymmetry,
Feeding difficulties,
Frontal bossing,
Gastroesophageal reflux,
Generalized hypotonia,
Global developmental delay,
Hyperplasia of the maxilla,
Hypotonia,
Intellectual disability,
Long hallux,
Low-set ears,
Lumbar hyperlordosis,
Mitral regurgitation,
Motor delay,
Motor stereotypy,
Myopia,
Narrow palate,
Open mouth,
Optic atrophy,
Osteochondritis dissecans,
Overlapping toe,
Pectus carinatum,
Pes planus,
Posteriorly rotated ears,
Scoliosis,
Seizure,
Self-injurious behavior,
Strabismus,
Thoracic kyphoscoliosis,
Vertebral clefting,
Vertebral fusion,
Wide nasal bridge
[+]
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Mouse (10 sources):
abnormal bone mineralization,
abnormal cervical vertebrae morphology,
abnormal neurocranium morphology,
abnormal sternum morphology,
abnormal sternum ossification,
abnormal thoracic cage shape,
failure of palatal shelf elevation,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
palatal shelves fail to meet at midline
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.