Monarch Ortholog Phenotypes
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Mouse (21 sources):
abnormal amacrine cell morphology,
abnormal embryo size,
abnormal retina inner nuclear layer thickness,
abnormal skin appearance,
decreased cellular sensitivity to gamma-irradiation,
decreased sensitivity to induced cell death,
decreased thymocyte apoptosis,
immune system phenotype,
increased circulating interleukin-6 level,
increased circulating tumor necrosis factor level,
increased incidence of tumors by chemical induction,
increased interleukin-6 secretion,
increased retina apoptosis,
increased sensitivity to induced morbidity/mortality,
increased susceptibility to bacterial infection induced morbidity/mortality,
increased susceptibility to injury,
increased T cell derived lymphoma incidence,
increased tumor necrosis factor secretion,
preweaning lethality, incomplete penetrance,
thin retina outer nuclear layer,
vision/eye phenotype
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