abnormal granulocyte differentiation, abnormal humoral immune response, abnormal interferon level, abnormal interleukin level, abnormal intestinal goblet cell morphology, abnormal intestinal smooth muscle morphology, abnormal leukocyte physiology, abnormal long bone metaphysis morphology, abnormal lymph node germinal center morphology, abnormal lymphopoiesis, abnormal macrophage chemotaxis, abnormal monocyte differentiation, abnormal mononuclear cell differentiation, abnormal myelopoiesis, abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal osteoclast physiology, abnormal platelet activation, abnormal pulmonary alveolus morphology, abnormal skeleton physiology, abnormal spleen marginal zone macrophage morphology, abnormal T cell differentiation, absent marginal zone B cells, decreased alpha-beta T cell number, decreased apoptosis, decreased body size, decreased bone marrow cell number, decreased bone strength, decreased bone trabecula number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased cytotoxic T cell cytolysis, decreased pre-B cell number, decreased pro-B cell number, decreased susceptibility to graft versus host disease, decreased susceptibility to parasitic infection, decreased thymocyte number, decreased trabecular bone thickness, decreased trabecular bone volume, enlarged lymph nodes, enlarged thymus, ileum inflammation, impaired natural killer cell mediated cytotoxicity, increased anti-chromatin antibody level, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased anti-single stranded DNA antibody level, increased autoantibody level, increased B-1 B cell number, increased B cell derived lymphoma incidence, increased CD8-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased circulating interleukin-6 level, increased dendritic cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased IgG2a level, increased interferon-beta secretion, increased macrophage cell number, increased mast cell degranulation, increased neutrophil cell number, increased NK cell number, increased osteoclast cell number, increased spleen weight, increased susceptibility to systemic lupus erythematosus, increased tumor necrosis factor secretion, lung hemorrhage, premature death, small thymus, spleen hyperplasia