| Monarch Ortholog Phenotypes
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Human (42 sources):
Abnormality of the digestive system,
Abnormality of the immune system,
Absent outer dynein arms,
Airway obstruction,
Asplenia,
Asthma,
Atelectasis,
Bronchiectasis,
Chronic bronchitis,
Chronic otitis media,
Chronic sinusitis,
Ciliary dyskinesia,
Clubbing of fingers,
Conductive hearing impairment,
Corneal dystrophy,
Cough,
Delayed speech and language development,
Dextrocardia,
Ectopic pregnancy,
Glue ear,
Halitosis,
Headache,
Hydrocephalus,
Immotile cilia,
Impaired nasal mucociliary clearance,
Infertility,
Miscarriage,
Nasal congestion,
Nasal polyposis,
Pectus excavatum,
Pneumonia,
Recurrent otitis media,
Recurrent respiratory infections,
Reduced sperm motility,
Respiratory distress,
Respiratory insufficiency,
Respiratory insufficiency due to defective ciliary clearance,
Rhinitis,
Scoliosis,
Situs inversus totalis,
Tachypnea,
Ventriculomegaly
[+]
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Mouse (10 sources):
abnormal brain ependyma morphology,
asthenozoospermia,
domed cranium,
enlarged lateral ventricles,
immotile respiratory cilia,
increased forebrain size,
postnatal lethality, incomplete penetrance,
situs inversus,
situs inversus with levocardia,
thin cerebral cortex
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.