abnormal splenic cell ratio, abnormal T cell activation, decreased acute inflammation, decreased B-1 B cell number, decreased B cell apoptosis, decreased B cell proliferation, decreased CD4-positive, alpha beta T cell number, decreased central memory CD4-positive, alpha-beta T cell number, decreased circulating tumor necrosis factor level, decreased fibroblast cell migration, decreased fibroblast chemotaxis, decreased follicular B cell number, decreased germinal center B cell number, decreased immature B cell number, decreased interleukin-6 secretion, decreased marginal zone B cell number, decreased mature B cell number, decreased memory B cell number, decreased memory T cell number, decreased regulatory T cell number, decreased single-positive T cell number, dissociated hepatocytes, embryonic lethality during organogenesis, complete penetrance, impaired macrophage chemotaxis, impaired neutrophil recruitment, increased B cell apoptosis, increased B cell proliferation, increased cell proliferation, increased cellular sensitivity to gamma-irradiation, increased enterocyte apoptosis, increased fibroblast apoptosis, increased hepatocyte apoptosis, increased IgG1 level, increased macrophage apoptosis, increased plasma cell number, increased regulatory T cell number, increased response to antigen, increased skeletal muscle fiber number, lethality throughout fetal growth and development, complete penetrance, liver/biliary system phenotype, liver hemorrhage, no abnormal phenotype detected, prenatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, small liver