chd2 Phenotypes

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Phenotypes

Gene Literature (9)

Nucleotides (232)

Interactants (236)

XB-GENEPAGE-950754

Gene Symbol: chd2 Gene Name: chromodomain helicase DNA binding protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (1 source), abnormally localised neural progenitor cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: chd2 manipulated (2 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
autism spectrum disorder (1AP source, 1 EP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + chd2 CRISPR (1 source), Xtr Wt + chd2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (55 sources): Abnormal brain FDG positron emission tomography, Abnormal brainstem morphology, Abnormality of the dentition, Abnormal periventricular white matter morphology, Aggressive behavior, Ataxia, Atonic seizure, Atypical absence seizure, Atypical behavior, Autistic behavior, Bilateral tonic-clonic seizure, Cutaneous photosensitivity, Depressed nasal bridge, Developmental regression, Downslanted palpebral fissures, Dysarthria, Dysphagia, EEG abnormality, EEG with abnormally slow frequencies, EEG with focal sharp slow waves, EEG with spike-wave complexes (>3.5 Hz), Encephalopathy, Enlarged cisterna magna, Epileptic encephalopathy, Falls, Febrile seizure (within the age range of 3 months to 6 years), Focal-onset seizure, Frontotemporal cerebral atrophy, Gastroesophageal reflux, Generalized myoclonic-atonic seizure, Generalized myoclonic seizure, Generalized non-motor (absence) seizure, Generalized tonic seizure, Gingival overgrowth, Global developmental delay, High forehead, Hyperactivity, Hypoplasia of the corpus callosum, Impulsivity, Intellectual disability, Intellectual disability, progressive, Intellectual disability, severe, Low-set ears, Macrocephaly, Mental deterioration, Myoclonus, obsolete Psychomotor retardation, Personality disorder, Photosensitive tonic-clonic seizure, Posteriorly rotated ears, Ptosis, Recurrent respiratory infections, Seizure, Status epilepticus, Tented upper lip vermilion [+]
Mouse (45 sources): abnormal blood cell morphology/development, abnormal body length, abnormal bone mineralization, abnormal erythropoiesis, abnormal grip strength, abnormal kidney morphology, abnormal prepulse inhibition, cardiac fibrosis, cortical renal glomerulopathies, decreased birth body size, decreased body length, decreased body size, decreased bone mineral content, decreased erythrocyte cell number, decreased fetal size, decreased hemoglobin content, decreased survivor rate, decreased white adipose tissue amount, disheveled coat, enlarged heart atrium, enlarged lymph nodes, fetal growth retardation, heart inflammation, increased CD4-positive, alpha beta T cell number, increased cellular sensitivity to methylmethanesulfonate, increased cellular sensitivity to ultraviolet irradiation, increased cellular sensitivity to X-ray irradiation, increased grip strength, increased lymphoma incidence, increased spleen red pulp amount, increased T cell derived lymphoma incidence, lethality throughout fetal growth and development, incomplete penetrance, lipidosis, lymphoid hyperplasia, myocardial fiber degeneration, pale kidney, postnatal lethality, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance, pulmonary alveolar edema, pulmonary alveolar hemorrhage, uterus cyst [+]
View all ortholog results at Monarch