stk4 Phenotypes

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Phenotypes

Gene Literature (3)

Nucleotides (148)

Interactants (479)

XB-GENEPAGE-955919

Gene Symbol: stk4 Gene Name: serine/threonine kinase 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: stk4 assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (8 sources): Atrial septal defect, Immunodeficiency, Lymphopenia, Neutropenia, Recurrent bacterial infections, Recurrent fungal infections, Recurrent viral infections, Verrucae
Mouse (42 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal CD4-positive T cell differentiation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal dendritic cell physiology, abnormal humoral immune response, abnormal immune system organ morphology, abnormal leukocyte adhesion, abnormal leukocyte migration, abnormal marginal zone B cell morphology, abnormal memory T cell number, abnormal Peyer's patch germinal center morphology, abnormal Peyer's patch T cell area morphology, abnormal spleen B cell follicle morphology, abnormal T cell differentiation, decreased B-1 B cell number, decreased B-2 B cell number, decreased CD11b-high dendritic cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased marginal zone B cell number, decreased myeloid dendritic cell number, decreased single-positive T cell number, decreased spleen white pulp amount, impaired humoral immune response, increased B-1b cell number, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased dendritic cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased histiocytic sarcoma incidence, increased interferon-gamma secretion, increased interleukin-2 secretion, increased interleukin-4 secretion, increased macrophage cell number, increased neutrophil cell number, increased NK cell number, increased single-positive T cell number, increased T cell apoptosis, increased T cell proliferation, increased thymocyte number, no abnormal phenotype detected [+]
View all ortholog results at Monarch