chd8 Phenotypes

Phenotypes

XB-GENEPAGE-966846

Gene Symbol: chd8 Gene Name: chromodomain helicase DNA binding protein 8

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (1 source), abnormally localised neural progenitor cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: chd8 manipulated (2 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
autism spectrum disorder (1AP source, 1 EP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + chd8 CRISPR (1 source), Xtr Wt + chd8 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (28 sources): abnormal forebrain development, abnormal hindbrain development, abnormal inner cell mass morphology, abnormal intestinal transit time, abnormal midbrain development, abnormal miniature inhibitory postsynaptic currents, abnormal nervous system development, abnormal neuron physiology, abnormal optic vesicle formation, abnormal social investigation, absent mesoderm, decreased intestine length, decreased locomotor activity, decreased startle reflex, embryonic growth arrest, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, excessive vocalization, failure of primitive streak formation, impaired learning, increased anxiety-related response, increased brain weight, increased ectoderm apoptosis, increased grooming behavior, increased prepulse inhibition, increased thigmotaxis, inner cell mass degeneration, preweaning lethality, complete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (28 sources): abnormal forebrain development, abnormal hindbrain development, abnormal inner cell mass morphology, abnormal intestinal transit time, abnormal midbrain development, abnormal miniature inhibitory postsynaptic currents, abnormal nervous system development, abnormal neuron physiology, abnormal optic vesicle formation, abnormal social investigation, [+]