Axial hypotonia, Babinski sign, Cellulitis, Cerebral atrophy, Cerebral hypomyelination, Choreoathetosis, CNS hypomyelination, Cognitive impairment, Constipation, Decreased motor nerve conduction velocity, Delayed gross motor development, Demyelinating motor neuropathy, Distal sensory impairment, Dysarthria, Dysmetria, Dystonia, Epicanthus, Erysipelas, Facial palsy, Global developmental delay, Head titubation, Hydrocele testis, Hyperkeratosis, Hyperreflexia, Hypoplasia of the corpus callosum, Intention tremor, Leukodystrophy, Leukoencephalopathy, Lichenification, Lower limb spasticity, Lymphedema, Motor delay, Myopia, Neoplasm of the skin, obsolete Difficulty walking, Optic atrophy, Pedal edema, Pes cavus, Poor speech, Predominantly lower limb lymphedema, Progressive spasticity, Recurrent skin infections, Rigidity, Rotary nystagmus, Scoliosis, Seizure, Sensorineural hearing impairment, Sensory axonal neuropathy, Slow saccadic eye movements, Somatic sensory dysfunction, Spastic gait, Spastic paraparesis, Spastic paraplegia, Specific learning disability, Strabismus, Toenail dysplasia, Upper limb spasticity, Urinary bladder sphincter dysfunction, Urinary incontinence, Varicose veins