| Monarch Ortholog Phenotypes
|
Human (22 sources):
Abnormal cerebral vascular morphology,
Abnormality of skin pigmentation,
Aplasia/Hypoplasia of the skin,
Arterial thrombosis,
Blindness,
Cerebral hemorrhage,
Cerebral venous thrombosis,
Deep venous thrombosis,
Disseminated intravascular coagulation,
Gangrene,
Hypercoagulability,
Pulmonary embolism,
Purpura,
Reduced protein S activity,
Retinopathy,
Skin ulcer,
Subcutaneous hemorrhage,
Superficial thrombophlebitis,
Thin skin,
Thrombophlebitis,
Venous insufficiency,
Warfarin-induced skin necrosis
[+]
|
Mouse (20 sources):
abnormal blood coagulation,
abnormal brain vasculature morphology,
abnormal neocortex morphology,
abnormal response/metabolism to endogenous compounds,
abnormal thrombosis,
abnormal vitelline vasculature morphology,
blood vessel congestion,
brain vascular congestion,
bruising,
cardiovascular system phenotype,
decreased bleeding time,
decreased hepatocyte number,
increased sensitivity to induced morbidity/mortality,
increased susceptibility to induced thrombosis,
increased vascular permeability,
lethality throughout fetal growth and development, complete penetrance,
no abnormal phenotype detected,
perinatal lethality, complete penetrance,
prenatal lethality, incomplete penetrance,
vascular smooth muscle hypoplasia
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.