sgms1 Phenotypes

Phenotypes

XB-GENEPAGE-986772

Gene Symbol: sgms1 Gene Name: sphingomyelin synthase 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: sgms1 assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (41 sources): abnormal adipose tissue amount, abnormal ceramide level, abnormal circulating alkaline phosphatase level, abnormal circulating amylase level, abnormal cytokine level, abnormal lipid level, abnormal mean corpuscular hemoglobin, abnormal pancreatic islet morphology, abnormal Sertoli cell barrier function, abnormal Sertoli cell barrier morphology, abnormal spermatid morphology, abnormal sphingolipid level, abnormal sphingomyelin level, absent acrosome, absent sperm flagellum, decreased circulating alanine transaminase level, decreased circulating interleukin-6 level, decreased circulating tumor necrosis factor level, decreased insulin secretion, decreased interleukin-6 secretion, decreased litter size, decreased liver weight, decreased male germ cell number, decreased mean corpuscular hemoglobin, decreased plasmalogen level, decreased tumor necrosis factor secretion, decreased unsaturated fatty acids level, decreased white adipose tissue amount, homeostasis/metabolism phenotype, improved glucose tolerance, increased bone mineral content, increased circulating alkaline phosphatase level, increased circulating amylase level, increased grip strength, increased insulin sensitivity, increased lean body mass, increased testis apoptosis, oxidative stress, premature death, reduced male fertility, seminiferous tubule degeneration [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (41 sources): abnormal adipose tissue amount, abnormal ceramide level, abnormal circulating alkaline phosphatase level, abnormal circulating amylase level, abnormal cytokine level, abnormal lipid level, abnormal mean corpuscular hemoglobin, abnormal pancreatic islet morphology, abnormal Sertoli cell barrier function, abnormal Sertoli cell barrier morphology, [+]