The polg2 gene encodes DNA polymerase gamma subunit 2, an accessory subunit of the mitochondrial DNA polymerase complex. This protein is nuclear-encoded and imported into mitochondria, where it functio...[+]

The polg2 gene encodes DNA polymerase gamma subunit 2, an accessory subunit of the mitochondrial DNA polymerase complex. This protein is nuclear-encoded and imported into mitochondria, where it functions as a processivity factor for the catalytic subunit, enhancing DNA binding and primer recognition during mitochondrial DNA replication and repair. Its expression supports mitochondrial biogenesis in early embryogenesis and oogenesis. [-]

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