Multifunctional protein that functions as a downstream effector of ralA and ralB (PubMed:15511640). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity...[+]

Multifunctional protein that functions as a downstream effector of ralA and ralB (PubMed:15511640). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of ralA. Recruited to mitochondrion by ralA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L. Acts on the cytoskeleton, to regulate pigment distribution and to regulate gastrulation (PubMed:15511640).
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD