Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, ...[+]

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.; Prothrombin [-]

             thrombophilia
             cerebral infarction
             cerebrovascular disease
             thrombophilia due to thrombin defect
             prothrombin thrombophilia

          THROMBOPHILIA DUE TO THROMBIN DEFECT; THPH1
          PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2; RPRGL2
          PROTHROMBIN DEFICIENCY, CONGENITAL

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD