The ppp2r2b gene encodes a regulatory b subunit of protein phosphatase 2a (pp2a), specifically forming part of the pp2a b55 subfamily. The encoded protein is a cytoplasmic and nuclear localized signali...[+]

The ppp2r2b gene encodes a regulatory b subunit of protein phosphatase 2a (pp2a), specifically forming part of the pp2a b55 subfamily. The encoded protein is a cytoplasmic and nuclear localized signaling molecule involved in cell cycle regulation, particularly during meiotic maturation by modulating cdk1-cyclin b activity through dephosphorylation events. Expression patterns are associated with the developing brain, eye, neural tube, otic vesicle, and somites. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD