Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Br J Pharmacol
2008 Feb 01;1534:792-804. doi: 10.1038/sj.bjp.0707612.
Show Gene links
Show Anatomy links
Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo.
Rahman S
,
Zhang Z
,
Papke RL
,
Crooks PA
,
Dwoskin LP
,
Bardo MT
.
???displayArticle.abstract???
Systemic administration of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), an antagonist of nicotinic acetylcholine receptors (nAChRs) attenuated the nicotine-induced increase in dopamine levels in nucleus accumbens (NAcc).Using in vivo microdialysis, we investigated the effects of local perfusion of the novel nAChR antagonist bPiDDB into the NAcc or ventral tegmental area (VTA) on increased extracellular dopamine in NAcc, induced by systemic nicotine. We also examined the concentration-dependent effects of bPiDDB on the acetylcholine (ACh)-evoked response of specific recombinant neuronal nAChR subtypes expressed in Xenopus oocytes, using electrophysiological methods.Nicotine (0.4 mg kg(-1), s.c.) increased extracellular dopamine in NAcc, which was attenuated by intra-VTA perfusion of mecamylamine (100 microM). Intra-VTA perfusion of bPiDDB (1 and 10 microM) reduced nicotine-induced increases in extracellular dopamine in NAcc. In contrast, intra-NAcc perfusion of bPiDDB (1 or 10 microM) failed to alter the nicotine-induced increase in dopamine in NAcc. Intra-VTA perfusion of bPiDDB alone did not alter basal dopamine levels, compared to control, nor the increased dopamine in NAcc following amphetamine (0.5 mg kg(-1), s.c.). Using Xenopus oocytes, bPiDDB (0.01-100 microM) inhibited the response to ACh on specific combinations of rat neuronal nAChR subunits, with highest potency at alpha3beta4beta3 and lowest potency at alpha6/3beta2beta3.bPiDDB-Sensitive nAChRs involved in regulating nicotine-induced dopamine release are located in the VTA, rather than in the NAcc. As bPiDDB has properties different from the prototypical nAChR antagonist mecamylamine, further development may lead to novel nAChR antagonists for the treatment of tobacco dependence.
Alexander,
Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision).
2007, Pubmed
Alexander,
Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision).
2007,
Pubmed
Ayers,
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.
2002,
Pubmed
Balfour,
The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected].
2004,
Pubmed
Benwell,
Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine.
1995,
Pubmed
Benwell,
The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity.
1992,
Pubmed
Bonci,
The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction?
2003,
Pubmed
Bouzat,
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.
2004,
Pubmed
Brazell,
Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen.
1990,
Pubmed
Champtiaux,
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice.
2003,
Pubmed
Clarke,
Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons.
1985,
Pubmed
Coe,
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.
2005,
Pubmed
,
Xenbase
CORCORAN,
Mecamylamine in treatment of hypertensive disease; observations on an unusual neuromuscular complication.
1956,
Pubmed
Corrigall,
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.
1994,
Pubmed
Corrigall,
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine.
1992,
Pubmed
Damaj,
Pharmacological characterization of nicotine-induced seizures in mice.
1999,
Pubmed
Damaj,
In vivo characterization of a novel inhibitor of CNS nicotinic receptors.
2005,
Pubmed
Dani,
Synaptic plasticity and nicotine addiction.
2001,
Pubmed
Dani,
Nicotine addiction and comorbidity with alcohol abuse and mental illness.
2005,
Pubmed
Dani,
Roles of dopamine signaling in nicotine addiction.
2003,
Pubmed
DENNIS,
Mecamylamine in the treatment of hypertension.
1957,
Pubmed
Di Chiara,
Dopamine and drug addiction: the nucleus accumbens shell connection.
2004,
Pubmed
Dowell,
Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors.
2003,
Pubmed
,
Xenbase
Dwoskin,
Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.
2004,
Pubmed
FREIS,
Mecamylamine, a new, orally effective, hypotensive agent; experimental and clinical evaluation.
1956,
Pubmed
Fu,
Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo.
2000,
Pubmed
Gaimarri,
Regulation of neuronal nicotinic receptor traffic and expression.
2007,
Pubmed
Geldenhuys,
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.
2005,
Pubmed
Gotti,
Brain nicotinic acetylcholine receptors: native subtypes and their relevance.
2006,
Pubmed
Imperato,
Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats.
1986,
Pubmed
Klink,
Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.
2001,
Pubmed
Kohl,
Ethanol and negative feedback regulation of mesolimbic dopamine release in rats.
1998,
Pubmed
Lecca,
Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration.
2006,
Pubmed
Le Novère,
The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.
2002,
Pubmed
Lundahl,
Mecamylamine blockade of both positive and negative effects of IV nicotine in human volunteers.
2000,
Pubmed
Mansvelder,
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas.
2002,
Pubmed
Mansvelder,
Long-term potentiation of excitatory inputs to brain reward areas by nicotine.
2000,
Pubmed
Markou,
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat.
2001,
Pubmed
Marshall,
Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats.
1997,
Pubmed
McCallum,
Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys.
2006,
Pubmed
MCQUEEN,
Use of mecamylamine in the management of hypertension.
1957,
Pubmed
Mihalak,
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.
2006,
Pubmed
,
Xenbase
MOYER,
Laboratory and clinical observations on mecamylamine as a hypotensive agent.
1955,
Pubmed
Nashmi,
CNS localization of neuronal nicotinic receptors.
2006,
Pubmed
Neugebauer,
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
2006,
Pubmed
Nisell,
Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area.
1994,
Pubmed
Papke,
The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate.
2005,
Pubmed
,
Xenbase
Papke,
Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes.
2001,
Pubmed
,
Xenbase
Papke,
Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.
2002,
Pubmed
,
Xenbase
Picciotto,
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine.
1998,
Pubmed
Picciotto,
Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics.
2002,
Pubmed
Pidoplichko,
Nicotine activates and desensitizes midbrain dopamine neurons.
1997,
Pubmed
Quarta,
Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release.
2007,
Pubmed
Quik,
Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization.
2000,
Pubmed
Rahman,
Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the ventral tegmental area.
2002,
Pubmed
Rahman,
Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure.
2004,
Pubmed
Rahman,
The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.
2007,
Pubmed
Reid,
Pharmacological characterization of nicotine-induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse.
1999,
Pubmed
Rochel,
Acetylcholine receptor availability and transmission efficacy.
1987,
Pubmed
Rose,
Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.
1994,
Pubmed
Salminen,
Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.
2004,
Pubmed
Schoffelmeer,
Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation.
2002,
Pubmed
Sziráki,
Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens.
2002,
Pubmed
Tapper,
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.
2004,
Pubmed
Thielen,
Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats.
2004,
Pubmed
Wonnacott,
Nicotine: from molecular mechanisms to behaviour.
2005,
Pubmed
Wooltorton,
Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas.
2003,
Pubmed
