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Proc Natl Acad Sci U S A
1989 Sep 01;8617:6597-601.
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Magainins and the disruption of membrane-linked free-energy transduction.
Westerhoff HV
,
Jureti D
,
Hendler RW
,
Zasloff M
.
???displayArticle.abstract??? Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We report here that members of the magainin family--i.e., the 21-amino acid peptide PGLa and the 23-amino acid peptide magainin 2 amide (PGSa)--dissipate the electric potential across various energy-transducing membranes and thus uncouple respiration from other free-energy-requiring processes. We propose that this is a likely mechanism for the antimicrobial effects of these compounds.
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