Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
The competence of a cell to respond to the signalling molecule retinoic acid (RA) is thought to depend largely on its repertoire of cognate zinc finger nuclear receptors. XCYP26 is an RA hydroxylase that is expressed differentially during early Xenopus development. In Xenopus embryos, XCYP26 can rescue developmental defects induced by application of exogenous RA, suggesting that the enzymatic modifications introduced inhibit RA signalling activities in vivo. Alterations in the expression pattern of a number of different molecular markers for neural development induced upon ectopic expression of XCYP26 reflect a primary function of RA signalling in hindbrain development. Progressive inactivation of RA signalling results in a stepwise anteriorization of the molecular identity of individual rhombomeres. The expression pattern of XCYP26 during gastrulation appears to define areas within the prospective neural plate that develop in response to different concentrations of RA. Taken together, these observations appear to reflect an important regulatory function of XCYP26 for RA signalling; XCYP26-mediated modification of RA modulates its signalling activity and helps to establish boundaries of differentially responsive and non-responsive territories.
Abu-Abed,
Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.
1998, Pubmed
Abu-Abed,
Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha.
1998,
Pubmed
Beato,
Steroid hormone receptors: many actors in search of a plot.
1995,
Pubmed
Blumberg,
An essential role for retinoid signaling in anteroposterior neural patterning.
1997,
Pubmed
,
Xenbase
Bradley,
The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest.
1993,
Pubmed
,
Xenbase
Chen,
Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo.
1992,
Pubmed
Chen,
A concentration gradient of retinoids in the early Xenopus laevis embryo.
1994,
Pubmed
,
Xenbase
Chitnis,
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.
1995,
Pubmed
,
Xenbase
Cho,
Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.
1988,
Pubmed
,
Xenbase
Dekker,
Overexpression of a cellular retinoic acid binding protein (xCRABP) causes anteroposterior defects in developing Xenopus embryos.
1994,
Pubmed
,
Xenbase
Döring,
Gene structure of nuclear lamin LIII of Xenopus laevis; a model for the evolution of IF proteins from a lamin-like ancestor.
1990,
Pubmed
,
Xenbase
Durston,
Retinoic acid causes an anteroposterior transformation in the developing central nervous system.
1989,
Pubmed
,
Xenbase
Durston,
Retinoids and related signals in early development of the vertebrate central nervous system.
1998,
Pubmed
Eichele,
Retinoids and vertebrate limb pattern formation.
1989,
Pubmed
Fujii,
Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos.
1997,
Pubmed
Godsave,
Expression patterns of Hoxb genes in the Xenopus embryo suggest roles in anteroposterior specification of the hindbrain and in dorsoventral patterning of the mesoderm.
1994,
Pubmed
,
Xenbase
Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase
Hemmati-Brivanlou,
Cephalic expression and molecular characterization of Xenopus En-2.
1991,
Pubmed
,
Xenbase
Heyman,
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.
1992,
Pubmed
Hollemann,
Xenopus Xsal-1, a vertebrate homolog of the region specific homeotic gene spalt of Drosophila.
1996,
Pubmed
,
Xenbase
Hollemann,
The Xenopus homologue of the Drosophila gene tailless has a function in early eye development.
1998,
Pubmed
,
Xenbase
Isaacs,
Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification.
1992,
Pubmed
,
Xenbase
Kao,
Dorsalization of mesoderm induction by lithium.
1989,
Pubmed
,
Xenbase
Kastner,
Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.
1997,
Pubmed
Kastner,
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?
1995,
Pubmed
Kliewer,
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.
1992,
Pubmed
Kolm,
Xenopus hindbrain patterning requires retinoid signaling.
1997,
Pubmed
,
Xenbase
Köster,
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-beta family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity.
1991,
Pubmed
,
Xenbase
Lamb,
Neural induction by the secreted polypeptide noggin.
1993,
Pubmed
,
Xenbase
Leid,
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
1992,
Pubmed
Lohnes,
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
1994,
Pubmed
Maden,
The role of vitamin A in the development of the central nervous system.
1998,
Pubmed
Maden,
Vitamin A-deficient quail embryos have half a hindbrain and other neural defects.
1996,
Pubmed
Mangelsdorf,
The RXR heterodimers and orphan receptors.
1995,
Pubmed
Marshall,
Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity.
,
Pubmed
Niehrs,
Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid.
1994,
Pubmed
,
Xenbase
Oschwald,
Localization of a nervous system-specific class II beta-tubulin gene in Xenopus laevis embryos by whole-mount in situ hybridization.
1991,
Pubmed
,
Xenbase
Papalopulu,
Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos.
1991,
Pubmed
,
Xenbase
Penzel,
Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis.
1997,
Pubmed
,
Xenbase
Pijnappel,
The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification.
1993,
Pubmed
,
Xenbase
Ray,
CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family.
1997,
Pubmed
Sharpe,
Retinoid receptors promote primary neurogenesis in Xenopus.
1997,
Pubmed
,
Xenbase
Sive,
Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.
1990,
Pubmed
,
Xenbase
Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase
Turner,
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
1994,
Pubmed
,
Xenbase
van der Wees,
Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain.
1998,
Pubmed
,
Xenbase
White,
cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.
1997,
Pubmed
White,
Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase.
1996,
Pubmed
Wittbrodt,
Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin.
1994,
Pubmed
,
Xenbase
Zhang,
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.
1992,
Pubmed
Zhang,
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
1992,
Pubmed
Zile,
Vitamin A and embryonic development: an overview.
1998,
Pubmed
