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Mol Cell Biol
2002 Nov 01;2221:7484-90. doi: 10.1128/MCB.22.21.7484-7490.2002.
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hSWI/SNF-catalyzed nucleosome sliding does not occur solely via a twist-diffusion mechanism.
Aoyagi S
,
Hayes JJ
.
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Nucleosome remodeling by the hSWI/SNF complex and other chromatin remodeling complexes can cause translocation (sliding) of the histone octamer in cis along DNA. Structural and biochemical evidence suggest that sliding involves a DNA twist-diffusion process whereby the DNA rotates about the helical axis without major displacement from the surface of the nucleosome and that this process may be driven by torsional stress within the DNA. We report that hSWI/SNF efficiently catalyzes sliding of nucleosomes containing branched DNAs as steric blocks to twist-diffusion and a nick to allow dissipation of torsional stress within the nucleosome. These results suggest that SWI/SNF-catalyzed nucleosome sliding does not occur exclusively via a simple twist-diffusion mechanism and support models in which the DNA maintains its rotational orientation to and is at least partially separated from the histone surface during nucleosome translocation.
Aoyagi,
Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions.
2002, Pubmed,
Xenbase
Aoyagi,
Nucleosome remodeling by the human SWI/SNF complex requires transient global disruption of histone-DNA interactions.
2002,
Pubmed
,
Xenbase
Bazett-Jones,
The SWI/SNF complex creates loop domains in DNA and polynucleosome arrays and can disrupt DNA-histone contacts within these domains.
1999,
Pubmed
Blomquist,
Increased nuclear factor 1 binding to its nucleosomal site mediated by sequence-dependent DNA structure.
1999,
Pubmed
Boyer,
Roles of the histone H2A-H2B dimers and the (H3-H4)(2) tetramer in nucleosome remodeling by the SWI-SNF complex.
2000,
Pubmed
Chafin,
Human DNA ligase I efficiently seals nicks in nucleosomes.
2000,
Pubmed
,
Xenbase
Côté,
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex.
1994,
Pubmed
Côté,
Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding.
1998,
Pubmed
de la Serna,
Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.
2001,
Pubmed
Deuring,
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
2000,
Pubmed
Gavin,
SWI/SNF chromatin remodeling requires changes in DNA topology.
2001,
Pubmed
Guschin,
ATP-Dependent histone octamer mobilization and histone deacetylation mediated by the Mi-2 chromatin remodeling complex.
2000,
Pubmed
,
Xenbase
Hamiche,
ATP-dependent histone octamer sliding mediated by the chromatin remodeling complex NURF.
1999,
Pubmed
Havas,
Generation of superhelical torsion by ATP-dependent chromatin remodeling activities.
2000,
Pubmed
,
Xenbase
Imbalzano,
Nucleosome disruption by human SWI/SNF is maintained in the absence of continued ATP hydrolysis.
1996,
Pubmed
Imbalzano,
Facilitated binding of TATA-binding protein to nucleosomal DNA.
1994,
Pubmed
Jaskelioff,
SWI-SNF-mediated nucleosome remodeling: role of histone octamer mobility in the persistence of the remodeled state.
2000,
Pubmed
Jenuwein,
Translating the histone code.
2001,
Pubmed
Kingston,
ATP-dependent remodeling and acetylation as regulators of chromatin fluidity.
1999,
Pubmed
Kwon,
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex.
1994,
Pubmed
,
Xenbase
Längst,
Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer.
1999,
Pubmed
Längst,
Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors.
2001,
Pubmed
Lee,
hSWI/SNF disrupts interactions between the H2A N-terminal tail and nucleosomal DNA.
1999,
Pubmed
,
Xenbase
Lee,
The N-terminal tail of histone H2A binds to two distinct sites within the nucleosome core.
1997,
Pubmed
,
Xenbase
Logie,
Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays.
1997,
Pubmed
Luger,
Crystal structure of the nucleosome core particle at 2.8 A resolution.
1997,
Pubmed
Narlikar,
Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity.
2001,
Pubmed
Narlikar,
Cooperation between complexes that regulate chromatin structure and transcription.
2002,
Pubmed
Peterson,
Promoter targeting and chromatin remodeling by the SWI/SNF complex.
2000,
Pubmed
Polach,
Mechanism of protein access to specific DNA sequences in chromatin: a dynamic equilibrium model for gene regulation.
1995,
Pubmed
Schnitzler,
Direct imaging of human SWI/SNF-remodeled mono- and polynucleosomes by atomic force microscopy employing carbon nanotube tips.
2001,
Pubmed
Schnitzler,
Human SWI/SNF interconverts a nucleosome between its base state and a stable remodeled state.
1998,
Pubmed
Strahl,
The language of covalent histone modifications.
2000,
Pubmed
Studitsky,
Overcoming a nucleosomal barrier to transcription.
1995,
Pubmed
Thiriet,
Functionally relevant histone-DNA interactions extend beyond the classically defined nucleosome core region.
1998,
Pubmed
,
Xenbase
Vignali,
ATP-dependent chromatin-remodeling complexes.
2000,
Pubmed
Whitehouse,
Nucleosome mobilization catalysed by the yeast SWI/SNF complex.
1999,
Pubmed
Whitehouse,
Mechanisms for ATP-dependent chromatin remodelling.
2000,
Pubmed
Wolffe,
Chromatin disruption and modification.
1999,
Pubmed
Workman,
Alteration of nucleosome structure as a mechanism of transcriptional regulation.
1998,
Pubmed
Zhang,
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
2001,
Pubmed
