Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels.
Bourinet E
,
Zamponi GW
,
Stea A
,
Soong TW
,
Lewis BA
,
Jones LP
,
Yue DT
,
Snutch TP
.
???displayArticle.abstract???
The physiological and pharmacological properties of the alpha 1E calcium (Ca) channel subtype do not exactly match any of the established categories described for native neuronal Ca currents. Many of the key diagnostic features used to assign cloned Ca channels to their native counterparts, however, are dependent on a number of factors, including cellular environment, beta subunit coexpression, and modulation by second messengers and G-proteins. Here, by examining the intrinsic pore characteristics of a family of transiently expressed neuronal Ca channels, we demonstrate that the permeation properties of alpha 1E closely resemble those described for a subset of low-threshold Ca channels. The alpha 1A (P-/Q-type), alpha 1B (N-type), and alpha 1C (L-type) high-threshold Ca channels all exhibit larger whole-cell currents with barium (Ba) as the charge carrier as compared with Ca or strontium (Sr). In contrast, macroscopic alpha 1E currents are largest in Sr, followed by Ca and then Ba. The unique permeation properties of alpha 1E are maintained at the single-channel level, are independent of the nature of the expression system, and are not affected by coexpression of alpha 2 and beta subunits. Overall, the permeation characteristics of alpha 1E are distinct from those described for R-type currents and share some similarities with native low-threshold Ca channels.
Akaike,
Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones.
1989, Pubmed
Akaike,
Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones.
1989,
Pubmed
Almers,
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore.
1984,
Pubmed
Beam,
Calcium currents in embryonic and neonatal mammalian skeletal muscle.
1988,
Pubmed
Bean,
Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.
1985,
Pubmed
Bourinet,
Voltage-dependent facilitation of a neuronal alpha 1C L-type calcium channel.
1994,
Pubmed
,
Xenbase
Byerly,
Permeation and interaction of divalent cations in calcium channels of snail neurons.
1985,
Pubmed
Carbone,
Kinetics and selectivity of a low-voltage-activated calcium current in chick and rat sensory neurones.
1987,
Pubmed
Charnet,
Calcium currents recorded from a neuronal alpha 1C L-type calcium channel in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
de Leon,
Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels.
1995,
Pubmed
Dhallan,
Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons.
1990,
Pubmed
Dubel,
Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel.
1992,
Pubmed
Dunlap,
Exocytotic Ca2+ channels in mammalian central neurons.
1995,
Pubmed
Dzhura,
Expression of low-voltage activated Ca2+ channels from rat brain neurones in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Ellinor,
Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions.
1995,
Pubmed
,
Xenbase
Ellinor,
Functional expression of a rapidly inactivating neuronal calcium channel.
1993,
Pubmed
,
Xenbase
Fox,
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.
1987,
Pubmed
Fujita,
Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain.
1993,
Pubmed
Galli,
Inactivation of single Ca2+ channels in rat sensory neurons by extracellular Ca2+.
1994,
Pubmed
Hagiwara,
Studies of calcium channels in rat clonal pituitary cells with patch electrode voltage clamp.
1982,
Pubmed
Hell,
Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel alpha 1 subunits.
1993,
Pubmed
Hess,
Mechanism of ion permeation through calcium channels.
,
Pubmed
Hess,
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.
1986,
Pubmed
Hiriart,
Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assay.
1988,
Pubmed
Huguenard,
A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus.
1992,
Pubmed
Imredy,
Mechanism of Ca(2+)-sensitive inactivation of L-type Ca2+ channels.
1994,
Pubmed
Kasai,
Dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels in a mammalian neuroblastoma-glioma cell line.
1992,
Pubmed
McDonald,
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells.
1994,
Pubmed
Mori,
Primary structure and functional expression from complementary DNA of a brain calcium channel.
1991,
Pubmed
,
Xenbase
Neely,
Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Neveu,
Differential beta-adrenergic regulation and phenotypic modulation of voltage-gated calcium currents in rat aortic myocytes.
1994,
Pubmed
Nilius,
A novel type of cardiac calcium channel in ventricular cells.
,
Pubmed
Perez-Reyes,
Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase.
1994,
Pubmed
Regan,
Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis.
1991,
Pubmed
Sather,
Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits.
1993,
Pubmed
,
Xenbase
Shuba,
The effect of permeant ions on single calcium channel activation in mouse neuroblastoma cells: ion-channel interaction.
1991,
Pubmed
Soong,
Structure and functional expression of a member of the low voltage-activated calcium channel family.
1993,
Pubmed
Stea,
A beta-subunit normalizes the electrophysiological properties of a cloned N-type Ca2+ channel alpha 1-subunit.
1993,
Pubmed
,
Xenbase
Stea,
Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.
1994,
Pubmed
,
Xenbase
Stea,
Determinants of PKC-dependent modulation of a family of neuronal calcium channels.
1995,
Pubmed
,
Xenbase
Takahashi,
Kinetic properties of T-type Ca2+ currents in isolated rat hippocampal CA1 pyramidal neurons.
1991,
Pubmed
Tang,
Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel.
1993,
Pubmed
Tomlinson,
Functional properties of a neuronal class C L-type calcium channel.
1993,
Pubmed
,
Xenbase
Tsien,
Multiple types of neuronal calcium channels and their selective modulation.
1988,
Pubmed
Williams,
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.
1992,
Pubmed
,
Xenbase
Williams,
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
1992,
Pubmed
Williams,
Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
1994,
Pubmed
,
Xenbase
Yang,
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels.
1993,
Pubmed
,
Xenbase
Yue,
Permeation in the dihydropyridine-sensitive calcium channel. Multi-ion occupancy but no anomalous mole-fraction effect between Ba2+ and Ca2+.
1990,
Pubmed
Zamponi,
Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.
1996,
Pubmed
,
Xenbase
Zhang,
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons.
1993,
Pubmed
,
Xenbase
