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XB-ART-16683
Bioessays 1997 Apr 01;194:281-4. doi: 10.1002/bies.950190404.
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Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms.

Holley SA , Ferguson EL .


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Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor-beta family member dpp patterns the embryonic dorsal-ventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal-ventral patterning in the zebrafish Danio rerio. Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate.

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Species referenced: Xenopus laevis
Genes referenced: bmp4 dspp