Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-5320
Dev Genes Evol 2003 Jul 01;2137:355-9. doi: 10.1007/s00427-003-0328-6.
Show Gene links Show Anatomy links

Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.

Moreau N , Gaultier A , Cousin H , Darribère T .


???displayArticle.abstract???
Dystroglycan is a cell surface receptor involved in the pathogenesis of muscular dystrophy, and plays a critical role in the assembly and homeostasis of basement membranes. Since data about the amphibian homologue are limited, we have cloned the full-length dystroglycan cDNAs from the frog Xenopus laevis. Using in situ hybridization, we show that mRNA expression is dynamic, particularly in the notochord at the end of gastrulation and during neurulation, suggesting that the protein might play unexplored roles in the specification and/or formation of this tissue. Subsequently, the transcripts are detected in the otic vesicle, the developing brain, and in mesenchymal cells of the visceral arches, as well as in pharyngeal endoderm, the pronephros, pronephric ducts, proctodaeum and the somites.

???displayArticle.pubmedLink??? 12739143
???displayArticle.link??? Dev Genes Evol
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: dag1

References [+] :
Cohen, Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis. 1995, Pubmed, Xenbase