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XB-ART-36019
Bioorg Med Chem Lett 2007 Mar 15;176:1520-2. doi: 10.1016/j.bmcl.2007.01.003.
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Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.

Leonik FM , Papke RL , Horenstein NA .


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The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively.

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