Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Neuron
2009 Jan 15;611:101-12. doi: 10.1016/j.neuron.2008.11.009.
Show Gene links
Show Anatomy links
Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction.
Morimoto-Tomita M
,
Zhang W
,
Straub C
,
Cho CH
,
Kim KS
,
Howe JR
,
Tomita S
.
???displayArticle.abstract???
Neuronal AMPA receptors autoinactivate at high concentrations of glutamate, i.e., the current declines at glutamate concentrations above 10-100 microM. The mechanisms underlying this phenomenon are unclear. Stargazin-like TARPs are AMPA receptor auxiliary subunits that modulate receptor trafficking and channel properties. Here, we found that neuronal AMPA receptors and recombinant AMPA receptors coexpressed with stargazin autoinactivate at high concentrations of glutamate, whereas recombinant AMPA receptors expressed alone do not. The reduction of currents at high glutamate concentrations is not associated with a reduction of AMPA receptor number, but rather with the loss of stargazin-associated allosteric modulation of channel gating. We show that receptor desensitization promotes the dissociation of TARP-AMPA receptor complexes in a few milliseconds. This dissociation mechanism contributes to synaptic short-term modulation. The results demonstrate a mechanism for dynamic regulation of AMPA receptor activity to tune synaptic strength.
Armstrong,
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
2006, Pubmed,
Xenbase
Armstrong,
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
2006,
Pubmed
,
Xenbase
Barry,
Receptor trafficking and the plasticity of excitatory synapses.
2002,
Pubmed
Chen,
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.
,
Pubmed
Chen,
Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors.
2003,
Pubmed
,
Xenbase
Cho,
Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents.
2007,
Pubmed
Colquhoun,
Activation of ion channels in the frog end-plate by high concentrations of acetylcholine.
1988,
Pubmed
Dingledine,
The glutamate receptor ion channels.
1999,
Pubmed
Fukata,
Molecular constituents of neuronal AMPA receptors.
2005,
Pubmed
,
Xenbase
Fukaya,
Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites.
2006,
Pubmed
Fukaya,
Spatial diversity in gene expression for VDCCgamma subunit family in developing and adult mouse brains.
2005,
Pubmed
Geoffroy,
Reduction of desensitization of a glutamate ionotropic receptor by antagonists.
1991,
Pubmed
,
Xenbase
Giniatullin,
Desensitization of nicotinic ACh receptors: shaping cholinergic signaling.
2005,
Pubmed
Gouaux,
Structure and function of AMPA receptors.
2004,
Pubmed
Hashimoto,
Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer.
1999,
Pubmed
Heine,
Surface mobility of postsynaptic AMPARs tunes synaptic transmission.
2008,
Pubmed
Hollmann,
Cloned glutamate receptors.
1994,
Pubmed
Jonas,
Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS.
1994,
Pubmed
Kandel,
The molecular biology of memory storage: a dialog between genes and synapses.
2001,
Pubmed
Kato,
New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors.
2007,
Pubmed
Kott,
Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family.
2007,
Pubmed
,
Xenbase
Lerma,
Kainate receptor physiology.
2006,
Pubmed
Malenka,
Long-term potentiation--a decade of progress?
1999,
Pubmed
Malinow,
AMPA receptor trafficking and synaptic plasticity.
2002,
Pubmed
Mayer,
Structure and function of glutamate receptor ion channels.
2004,
Pubmed
Milstein,
TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
2007,
Pubmed
Nakagawa,
Structure and different conformational states of native AMPA receptor complexes.
2005,
Pubmed
Nicoll,
Synaptic plasticity at hippocampal mossy fibre synapses.
2005,
Pubmed
Nicoll,
Auxiliary subunits assist AMPA-type glutamate receptors.
2006,
Pubmed
Partin,
Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.
1994,
Pubmed
,
Xenbase
Paternain,
Activation and desensitization properties of native and recombinant kainate receptors.
1998,
Pubmed
Patneau,
Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons.
1991,
Pubmed
Priel,
Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.
2005,
Pubmed
,
Xenbase
Raman,
The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus.
1992,
Pubmed
Robert,
How AMPA receptor desensitization depends on receptor occupancy.
2003,
Pubmed
Rouach,
TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity.
2005,
Pubmed
Seeburg,
The TINS/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels.
1993,
Pubmed
Sheng,
Postsynaptic signaling and plasticity mechanisms.
2002,
Pubmed
Sommer,
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
1990,
Pubmed
Song,
Regulation of AMPA receptors during synaptic plasticity.
2002,
Pubmed
Tomita,
Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.
2005,
Pubmed
Tomita,
AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity.
2007,
Pubmed
,
Xenbase
Tomita,
Stargazin modulates AMPA receptor gating and trafficking by distinct domains.
2005,
Pubmed
,
Xenbase
Tomita,
Stargazin interacts functionally with the AMPA receptor glutamate-binding module.
2007,
Pubmed
Tomita,
Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
2004,
Pubmed
,
Xenbase
Tomita,
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins.
2003,
Pubmed
Turetsky,
Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms.
2005,
Pubmed
Vandenberghe,
Stargazin is an AMPA receptor auxiliary subunit.
2005,
Pubmed
Vlachová,
The action of excitatory amino acids on chick spinal cord neurones in culture.
1987,
Pubmed
Walker,
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins.
2006,
Pubmed
,
Xenbase
Yamazaki,
A novel action of stargazin as an enhancer of AMPA receptor activity.
2004,
Pubmed
,
Xenbase
Zhang,
The relationship between agonist potency and AMPA receptor kinetics.
2006,
Pubmed
Ziff,
TARPs and the AMPA receptor trafficking paradox.
2007,
Pubmed
