Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
1987 Nov 01;611:3493-8. doi: 10.1002/j.1460-2075.1987.tb02674.x.
Show Gene links
Show Anatomy links
The accumulation of mature RNA for the Xenopus laevis ribosomal protein L1 is controlled at the level of splicing and turnover of the precursor RNA.
Caffarelli E
,
Fragapane P
,
Gehring C
,
Bozzoni I
.
???displayArticle.abstract???
A specific control regulates, at the level of RNA splicing, the expression of the L1 ribosomal protein gene in Xenopus laevis. Under particular conditions, which can be summarized as an excess of free L1 protein, a precursor RNA which still contains two of the nine introns of the L1 gene accumulates. In addition to the splicing block the two intron regions undergo specific endonucleolytic cleavages which produce abortive truncated molecules. The accumulation of mature L1 RNA therefore results from the regulation of the nuclear stability of its precursor RNA. We propose that a block to splicing can permit the attack of specific intron regions by nucleases which destabilize the pre-mRNA in the nucleus. Therefore the efficiency of splicing could indirectly control the stability of the pre-mRNA.
Abovich,
Effect of RP51 gene dosage alterations on ribosome synthesis in Saccharomyces cerevisiae.
1985, Pubmed
Abovich,
Effect of RP51 gene dosage alterations on ribosome synthesis in Saccharomyces cerevisiae.
1985,
Pubmed
Bollen,
Isolation of cloned ribosomal protein genes from the yeast Saccharomyces carlsbergensis.
1981,
Pubmed
Bozzoni,
Expression of two Xenopus laevis ribosomal protein genes in injected frog oocytes. A specific splicing block interferes with the L1 RNA maturation.
1984,
Pubmed
,
Xenbase
Bozzoni,
Isolation and structural analysis of ribosomal protein genes in Xenopus laevis. Homology between sequences present in the gene and in several different messenger RNAs.
1982,
Pubmed
,
Xenbase
Brawerman,
Determinants of messenger RNA stability.
1987,
Pubmed
Dabeva,
Autogenous regulation of splicing of the transcript of a yeast ribosomal protein gene.
1986,
Pubmed
elBaradi,
The cellular level of yeast ribosomal protein L25 is controlled principally by rapid degradation of excess protein.
1986,
Pubmed
Frendewey,
Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences.
1985,
Pubmed
Fried,
The genes for fifteen ribosomal proteins of Saccharomyces cerevisiae.
1981,
Pubmed
Gerke,
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA.
1986,
Pubmed
Grabowski,
Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate.
1984,
Pubmed
Green,
Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei.
1983,
Pubmed
,
Xenbase
Gurdon,
The transcription of 5 S DNA injected into Xenopus oocytes.
1978,
Pubmed
,
Xenbase
Hernandez,
Splicing of in vitro synthesized messenger RNA precursors in HeLa cell extracts.
1983,
Pubmed
Konarska,
Trans splicing of mRNA precursors in vitro.
1985,
Pubmed
Krämer,
Purification of a protein required for the splicing of pre-mRNA and its separation from the lariat debranching enzyme.
1985,
Pubmed
Loreni,
Nucleotide sequence of the L1 ribosomal protein gene of Xenopus laevis: remarkable sequence homology among introns.
1985,
Pubmed
,
Xenbase
Melton,
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
1984,
Pubmed
Pearson,
Yeast use translational control to compensate for extra copies of a ribosomal protein gene.
1982,
Pubmed
Pierandrei-Amaldi,
Ribosomal protein production in normal and anucleolate Xenopus embryos: regulation at the posttranscriptional and translational levels.
1985,
Pubmed
,
Xenbase
Pierandrei-Amaldi,
Expression of ribosomal-protein genes in Xenopus laevis development.
1982,
Pubmed
,
Xenbase
Reed,
Intron sequences involved in lariat formation during pre-mRNA splicing.
1985,
Pubmed
Ruskin,
Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing.
1985,
Pubmed
Ruskin,
Role of the 3' splice site consensus sequence in mammalian pre-mRNA splicing.
,
Pubmed
Ruskin,
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.
1984,
Pubmed
Solnick,
Alternative splicing caused by RNA secondary structure.
1985,
Pubmed
Tazi,
A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein.
1986,
Pubmed
Vaessen,
Post-transcriptional control of class I MHC mRNA expression in adenovirus 12-transformed cells.
1987,
Pubmed
Warner,
Saccharomyces cerevisiae coordinates accumulation of yeast ribosomal proteins by modulating mRNA splicing, translational initiation, and protein turnover.
1985,
Pubmed
Woolford,
Isolation of cloned DNA sequences containing ribosomal protein genes from Saccharomyces cerevisiae.
1979,
Pubmed
