Radford HE , Meijer HA , de Moor CH .

Wellcome Trust

	Fig. 1. The activation of CPE-mediated cytoplasmic polyadenylation. In immature oocytes, CPE containing mRNAs already contain all the proteins necessary for polyadenylation as well as the deadenylase PARN. During oocyte maturation, phosphorylation of CPEB causes a rearrangement of the complex that leads to the ejection of PARN and the activation of the poly(A) polymerase Gld-2. 4E: eIF4E, 4A: eIF4A. For further description of this process, see the text.
	Fig. 2. The signal transduction cascade leading to cytoplasmic polyadenylation during oocyte maturation. Schematic representation of the key signalling events in oocyte maturation and the role of cytoplasmic polyadenylation in this process. For a detailed description, see the text.
	Fig. 3. Four models of translation repression by CPEs. Schematic representation of some of the proposed translational repression mechanisms for CPE containing mRNAs. For a detailed description, see the text.

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