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Fischbarg J
,
Kuang KY
,
Vera JC
,
Arant S
,
Silverstein SC
,
Loike J
,
Rosen OM
.
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Water traverses the plasma membranes of some eukaryotic cells faster than can be explained by the water permeability of their lipid bilayers. This has led to a search for a water channel. Our previous work identified glucose transporters as candidates for such a channel. We report here that Xenopus laevis oocytes injected with mRNA encoding the brain/Hep G2, adult skeletal muscle/adipocyte, or liver forms of the glucose transporter exhibit an osmotic water permeability of their plasma membranes larger than that of untreated oocytes. The osmotic water permeability component attributable to glucose transporters increased an average of 4.8-fold in the injected oocytes. These studies provide direct evidence that the facilitative, sodium-independent mammalian glucose transporters serve as membrane water channels.
Alvarez,
Fourier transform infrared spectroscopic study of the structure and conformational changes of the human erythrocyte glucose transporter.
1987, Pubmed
Alvarez,
Fourier transform infrared spectroscopic study of the structure and conformational changes of the human erythrocyte glucose transporter.
1987,
Pubmed
Birnbaum,
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.
1986,
Pubmed
Birnbaum,
Identification of a novel gene encoding an insulin-responsive glucose transporter protein.
1989,
Pubmed
,
Xenbase
Brahm,
Kinetics of glucose transport in human erythrocytes.
1983,
Pubmed
Dick,
The effect of surface microvilli on the water permeability of single toad oocytes.
1970,
Pubmed
Fettiplace,
The influence of the lipid on the water permeability of artificial membranes.
1978,
Pubmed
Finkelstein,
The gramicidin A channel: a review of its permeability characteristics with special reference to the single-file aspect of transport.
1981,
Pubmed
Fischbarg,
Evidence that the glucose transporter serves as a water channel in J774 macrophages.
1989,
Pubmed
Fischbarg,
On the possible permeation of water across the glucose transporter.
1988,
Pubmed
Fukumoto,
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.
1989,
Pubmed
Fukumoto,
Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.
1988,
Pubmed
Gurdon,
Methods for nuclear transplantation in amphibia.
1977,
Pubmed
Helgerson,
Analysis of protein-mediated 3-O-methylglucose transport in rat erythrocytes: rejection of the alternating conformation carrier model for sugar transport.
1989,
Pubmed
James,
Molecular cloning and characterization of an insulin-regulatable glucose transporter.
1989,
Pubmed
Jones,
Monosaccharide transport proteins of the human erythrocyte membrane.
1981,
Pubmed
Jung,
Structural basis of human erythrocyte glucose transporter function in reconstituted system. Hydrogen exchange.
1986,
Pubmed
Kaestner,
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
1989,
Pubmed
Kayano,
Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.
1988,
Pubmed
Mueckler,
Sequence and structure of a human glucose transporter.
1985,
Pubmed
Sigler,
The effect of non-electrolyte osmolarity on frog oocytes. I. Volume changes.
1971,
Pubmed
Thorens,
Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells.
1988,
Pubmed
Vera,
Functional expression of mammalian glucose transporters in Xenopus laevis oocytes: evidence for cell-dependent insulin sensitivity.
1989,
Pubmed
,
Xenbase
Vera,
Reconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transporters.
1990,
Pubmed
,
Xenbase
