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In Xenopus and zebrafish embryos, elongation of the anterior-posterior body axis depends on convergent extension, a process that involves polarized cell movements and is regulated by non-canonical Wnt signaling. The mechanisms that control axis elongation of the mouse embryo are much less well understood. Here, we characterize the ENU-induced mouse mutation chato, which causes arrest at midgestation and defects characteristic of convergent extension mutants, including a shortened body axis, mediolaterally extended somites and an open neural tube. The chato mutation disrupts Zfp568, a Krüppel-associated box (KRAB) domain zinc-finger protein. Morphometric analysis revealed that the definitive endoderm of mouse wild-type embryos undergoes cell rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body axis elongation in all embryonic tissues through a process independent of non-canonical Wnt signaling.
Bardet,
The ERRalpha orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation.
2005, Pubmed
Bardet,
The ERRalpha orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation.
2005,
Pubmed
Bellefroid,
The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.
1991,
Pubmed
,
Xenbase
Belo,
Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula.
1997,
Pubmed
,
Xenbase
Bertet,
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation.
2004,
Pubmed
Blankenship,
Multicellular rosette formation links planar cell polarity to tissue morphogenesis.
2006,
Pubmed
Candia,
Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.
1992,
Pubmed
Casademunt,
The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.
1999,
Pubmed
Cereghini,
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles.
1992,
Pubmed
Collignon,
Relationship between asymmetric nodal expression and the direction of embryonic turning.
1996,
Pubmed
Collignon,
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.
1996,
Pubmed
Concha,
Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis.
1998,
Pubmed
Copp,
The genetic basis of mammalian neurulation.
2003,
Pubmed
Crompton,
Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.
2007,
Pubmed
Curtin,
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.
2003,
Pubmed
Darken,
The planar polarity gene strabismus regulates convergent extension movements in Xenopus.
2002,
Pubmed
,
Xenbase
Davidson,
Neural tube closure in Xenopus laevis involves medial migration, directed protrusive activity, cell intercalation and convergent extension.
1999,
Pubmed
,
Xenbase
D'Avino,
crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis.
1998,
Pubmed
Echelard,
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
1993,
Pubmed
Elul,
Monopolar protrusive activity: a new morphogenic cell behavior in the neural plate dependent on vertical interactions with the mesoderm in Xenopus.
2000,
Pubmed
,
Xenbase
Elul,
Cellular mechanism underlying neural convergent extension in Xenopus laevis embryos.
1997,
Pubmed
,
Xenbase
Firulli,
Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.
1998,
Pubmed
García-García,
Analysis of mouse embryonic patterning and morphogenesis by forward genetics.
2005,
Pubmed
García-García,
Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.
2003,
Pubmed
Gebelein,
Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Krüppel-associated box protein.
2001,
Pubmed
George,
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.
1993,
Pubmed
Goto,
The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus.
2002,
Pubmed
,
Xenbase
Greene,
Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.
1998,
Pubmed
Hammerschmidt,
Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio.
1996,
Pubmed
Jessen,
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements.
2002,
Pubmed
Kasarskis,
A phenotype-based screen for embryonic lethal mutations in the mouse.
1998,
Pubmed
Keller,
Mediolateral cell intercalation in the dorsal, axial mesoderm of Xenopus laevis.
1989,
Pubmed
,
Xenbase
Kibar,
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
2001,
Pubmed
Kinder,
The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo.
1999,
Pubmed
Krebs,
Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.
2003,
Pubmed
Lawson,
Fate mapping the mouse embryo.
1999,
Pubmed
Lewis,
Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function.
2006,
Pubmed
Lints,
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
1993,
Pubmed
Lu,
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
2004,
Pubmed
,
Xenbase
Margolin,
Krüppel-associated boxes are potent transcriptional repression domains.
1994,
Pubmed
Matsui,
Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development.
2005,
Pubmed
,
Xenbase
Montcouquiol,
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.
2003,
Pubmed
Moon,
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.
1993,
Pubmed
,
Xenbase
Morin-Kensicki,
Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65.
2006,
Pubmed
Murdoch,
Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.
2001,
Pubmed
Murdoch,
Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.
2001,
Pubmed
Quertermous,
Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.
1994,
Pubmed
Rakeman,
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
2006,
Pubmed
Ruiz i Altaba,
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate.
1993,
Pubmed
,
Xenbase
Sumanas,
15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation.
2005,
Pubmed
Tada,
Non-canonical Wnt signalling and regulation of gastrulation movements.
2002,
Pubmed
,
Xenbase
Tada,
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
2000,
Pubmed
,
Xenbase
Tahinci,
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation.
2003,
Pubmed
,
Xenbase
Torban,
Genetic interaction between members of the Vangl family causes neural tube defects in mice.
2008,
Pubmed
Torban,
Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation.
2007,
Pubmed
Tremblay,
Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues.
2005,
Pubmed
Urrutia,
KRAB-containing zinc-finger repressor proteins.
2003,
Pubmed
von der Hardt,
The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion.
2007,
Pubmed
Wallingford,
Convergent extension: the molecular control of polarized cell movement during embryonic development.
2002,
Pubmed
,
Xenbase
Wallingford,
Neural tube closure requires Dishevelled-dependent convergent extension of the midline.
2002,
Pubmed
,
Xenbase
Wallingford,
Dishevelled controls cell polarity during Xenopus gastrulation.
2000,
Pubmed
,
Xenbase
Wang,
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.
2006,
Pubmed
,
Xenbase
Wang,
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
2006,
Pubmed
Warga,
Cell movements during epiboly and gastrulation in zebrafish.
1990,
Pubmed
Wilkinson,
Expression pattern of the mouse T gene and its role in mesoderm formation.
1990,
Pubmed
,
Xenbase
Wilkinson,
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse.
1989,
Pubmed
Wilson,
Cell rearrangement during gastrulation of Xenopus: direct observation of cultured explants.
1991,
Pubmed
,
Xenbase
Yamanaka,
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms.
2007,
Pubmed
Ybot-Gonzalez,
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.
2007,
Pubmed
Zhou,
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.
2001,
Pubmed
