Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Mol Biol Cell
2000 Jan 01;111:131-40. doi: 10.1091/mbc.11.1.131.
Show Gene links
Show Anatomy links
Differential induction of two p24delta putative cargo receptors upon activation of a prohormone-producing cell.
Kuiper RP
,
Waterham HR
,
Rötter J
,
Bouw G
,
Martens GJ
.
???displayArticle.abstract???
The p24 family consists of type I transmembrane proteins that are present abundantly in transport vesicles, may play a role in endoplasmic reticulum-to-Golgi cargo transport, and have been classified into subfamilies named p24alpha, -beta, -gamma, and -delta. We previously identified a member of the p24delta subfamily that is coordinately expressed with the prohormone proopiomelanocortin (POMC) in the melanotrope cells of the intermediate pituitary during black background adaptation of the amphibian Xenopus laevis ( approximately 30-fold increase in POMC mRNA). In this study, we report on the characterization of this p24delta member (Xp24delta(2)) and on the identification and characterization of a second member (Xp24delta(1)) that is also expressed in the melanotrope cells and that has 66% amino acid sequence identity to Xp24delta(2). The two p24delta members are ubiquitously expressed, but Xp24delta(2) is neuroendocrine enriched. During black background adaptation, the amount of the Xp24delta(2) protein in the intermediate pituitary was increased approximately 25 times, whereas Xp24delta(1) protein expression was increased only 2.5 times. Furthermore, the level of Xp24delta(2) mRNA was approximately 5-fold higher in the melanotrope cells of black-adapted animals than in those of white-adapted animals, whereas Xp24delta(1) mRNA expression was not induced. Therefore, the expression of Xp24delta(2) specifically correlates with the expression of POMC. Together, our findings suggest that p24delta proteins have a role in selective protein transport in the secretory pathway.
Aridor,
Cargo selection by the COPII budding machinery during export from the ER.
1998, Pubmed
Aridor,
Cargo selection by the COPII budding machinery during export from the ER.
1998,
Pubmed
Aridor,
Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport.
1995,
Pubmed
Balch,
Vesicular stomatitis virus glycoprotein is sorted and concentrated during export from the endoplasmic reticulum.
1994,
Pubmed
Bannykh,
The organization of endoplasmic reticulum export complexes.
1996,
Pubmed
Bannykh,
Membrane dynamics at the endoplasmic reticulum-Golgi interface.
1997,
Pubmed
Barlowe,
COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum.
1994,
Pubmed
Bednarek,
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.
1995,
Pubmed
Belden,
Erv25p, a component of COPII-coated vesicles, forms a complex with Emp24p that is required for efficient endoplasmic reticulum to Golgi transport.
1996,
Pubmed
Blum,
Intracellular localization and in vivo trafficking of p24A and p23.
1999,
Pubmed
Blum,
Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.
1996,
Pubmed
,
Xenbase
Cosson,
Coatomer interaction with di-lysine endoplasmic reticulum retention motifs.
1994,
Pubmed
de Rijk,
Morphology of the pars intermedia and the melanophore-stimulating cells in Xenopus laevis in relation to background adaptation.
1990,
Pubmed
,
Xenbase
Dominguez,
gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.
1998,
Pubmed
Dotman,
Dynamics of proopiomelanocortin and prohormone convertase 2 gene expression in Xenopus melanotrope cells during long-term background adaptation.
1998,
Pubmed
,
Xenbase
Elrod-Erickson,
Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations.
1996,
Pubmed
Fiedler,
Bimodal interaction of coatomer with the p24 family of putative cargo receptors.
1996,
Pubmed
Fiedler,
Sorting determinants in the transmembrane domain of p24 proteins.
1997,
Pubmed
Füllekrug,
Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.
1999,
Pubmed
Gerich,
Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.
1995,
Pubmed
Graham,
A new technique for the assay of infectivity of human adenovirus 5 DNA.
1973,
Pubmed
Hara-Kuge,
En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles.
1994,
Pubmed
Holthuis,
Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary.
1999,
Pubmed
,
Xenbase
Holthuis,
Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary.
1995,
Pubmed
,
Xenbase
Holthuis,
Molecular probing of the secretory pathway in peptide hormone-producing cells.
1995,
Pubmed
,
Xenbase
Hopkins,
Studies on secretory activity in the pars intermedia of Xenopus laevis 1: Fine structural changes related to the onset of secretory activity in vivo.
1970,
Pubmed
,
Xenbase
Hörer,
A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II.
1999,
Pubmed
Lavoie,
Roles for alpha(2)p24 and COPI in endoplasmic reticulum cargo exit site formation.
1999,
Pubmed
Letourneur,
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.
1994,
Pubmed
Majoul,
KDEL receptor (Erd2p)-mediated retrograde transport of the cholera toxin A subunit from the Golgi involves COPI, p23, and the COOH terminus of Erd2p.
1998,
Pubmed
Martens,
Physiologically-induced changes in proopiomelanocortin mRNA levels in the pituitary gland of the amphibian Xenopus laevis.
1987,
Pubmed
,
Xenbase
Martínez-Menárguez,
Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles.
1999,
Pubmed
Marzioch,
Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex.
1999,
Pubmed
Nickel,
p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway.
1997,
Pubmed
Nickel,
Biogenesis of COPI-coated transport vesicles.
1997,
Pubmed
Orci,
Bidirectional transport by distinct populations of COPI-coated vesicles.
1997,
Pubmed
Pepperkok,
Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo.
1993,
Pubmed
Presley,
ER-to-Golgi transport visualized in living cells.
1997,
Pubmed
Rojo,
Involvement of the transmembrane protein p23 in biosynthetic protein transport.
1997,
Pubmed
Scales,
Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI.
1997,
Pubmed
Schimmöller,
The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.
1995,
Pubmed
Schweizer,
Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus.
1990,
Pubmed
Sohn,
A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.
1996,
Pubmed
Stamnes,
An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.
1995,
Pubmed
Van Horssen,
Biosynthesis of secretogranin II in Xenopus intermediate pituitary.
1999,
Pubmed
,
Xenbase
Wada,
SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.
1991,
Pubmed
Wen,
p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans.
1999,
Pubmed
