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In this issue of Molecular Cell, Kimata et al. (2008) show that Cdc20 functions not only in the recruitment of substrates to the anaphase-promoting complex but also in its activation.
Au,
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
2002, Pubmed
Au,
Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.
2002,
Pubmed
Carroll,
The APC subunit Doc1 promotes recognition of the substrate destruction box.
2005,
Pubmed
Carroll,
The Doc1 subunit is a processivity factor for the anaphase-promoting complex.
2002,
Pubmed
Dube,
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.
2005,
Pubmed
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Xenbase
Hayes,
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C.
2006,
Pubmed
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Xenbase
Kimata,
A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment.
2008,
Pubmed
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Xenbase
Passmore,
Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.
2003,
Pubmed
Thornton,
An architectural map of the anaphase-promoting complex.
2006,
Pubmed
Thornton,
Precise destruction: an emerging picture of the APC.
2006,
Pubmed
Wendt,
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
2001,
Pubmed
Yamano,
Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts.
2004,
Pubmed
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Xenbase
