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Changes in the optic nerve following a crush lesion and during axonal regeneration have been studied in Xenopus tadpoles, using ultrastructural and immunohistological methods. Degeneration of both unmyelinated and myelinated axons is very rapid and leads to the formation, within 5 days, of a nerve which consists largely of degeneration debris and cells. Immunohistological analysis with monoclonal antibody 5F4 shows that there is a rapid and extensive microglial/macrophage response to crush of the nerve. Regenerating axons have begun to enter the distal stump by 5 days and grow along the outer part of the nerve in close approximation to the astrocytic glia limitans. Between 5 and 10 days after nerve crush, regenerating axons reach and pass the chiasma. Macrophages are seen in the nerve at the site of the lesion within 1 h, and the response peaks between 3-5 days, just before axonal regeneration gets under way.
Bastmeyer,
Growth of regenerating goldfish axons is inhibited by rat oligodendrocytes and CNS myelin but not but not by goldfish optic nerve tract oligodendrocytelike cells and fish CNS myelin.
1991, Pubmed
Bastmeyer,
Growth of regenerating goldfish axons is inhibited by rat oligodendrocytes and CNS myelin but not but not by goldfish optic nerve tract oligodendrocytelike cells and fish CNS myelin.
1991,
Pubmed
Bignami,
The fate of axonal debris in Wallerian degeneration of rat optic and sciatic nerves. Electron microscopy and immunofluorescence studies with neurofilament antisera.
1981,
Pubmed
Bohn,
Axonal interactions with connective tissue and glial substrata during optic nerve regeneration in Xenopus larvae and adults.
1982,
Pubmed
,
Xenbase
Brown,
Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth factor.
1991,
Pubmed
Caroni,
Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading.
1988,
Pubmed
Cima,
Development of the optic nerve in Xenopus laevis. I. Early development and organization.
1982,
Pubmed
,
Xenbase
Cohen,
The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons.
1987,
Pubmed
Cook,
The role of oligodendroglia and astroglia in Wallerian degeneration of the optic nerve.
1973,
Pubmed
David,
Macrophages can modify the nonpermissive nature of the adult mammalian central nervous system.
1990,
Pubmed
Dowding,
Diversity amongst the microglia in growing and regenerating fish CNS: immunohistochemical characterization using FL.1, an anti-macrophage monoclonal antibody.
1991,
Pubmed
Gaze,
Regeneration of optic fibres through the chiasma in Xenopus laevis tadpoles.
1990,
Pubmed
,
Xenbase
GAZE,
Regeneration of the optic nerve in Xenopus laevis.
1959,
Pubmed
,
Xenbase
GAZE,
The development, structure and composition of the optic nerve of Xenopus laevis (Daudin).
1961,
Pubmed
,
Xenbase
Giulian,
Interleukin-1 is an astroglial growth factor in the developing brain.
1988,
Pubmed
Giulian,
Interleukin 1 of the central nervous system is produced by ameboid microglia.
1986,
Pubmed
Goodbrand,
Microglia in tadpoles of Xenopus laevis: normal distribution and the response to optic nerve injury.
1991,
Pubmed
,
Xenbase
Harel,
Fish apolipoprotein-A-I has heparin binding activity: implication for nerve regeneration.
1990,
Pubmed
Harel,
Optic nerve regeneration in adult fish and apolipoprotein A-I.
1989,
Pubmed
Hopkins,
Laminin and optic nerve regeneration in the goldfish.
1985,
Pubmed
Ignatius,
Lipoprotein uptake by neuronal growth cones in vitro.
1987,
Pubmed
Lowenger,
Studies of the early stages of optic axon regeneration in the goldfish.
1988,
Pubmed
Lunn,
Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve.
1989,
Pubmed
Mahley,
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
1988,
Pubmed
Matsumoto,
Long-term survival of centrally projecting axons in the optic nerve of the frog following destruction of the retina.
1981,
Pubmed
Matthey,
[Not Available].
1927,
Pubmed
McLoon,
Transient expression of laminin in the optic nerve of the developing rat.
1988,
Pubmed
Mori,
Identification of microglia in light and electron microscopy.
1969,
Pubmed
Nathan,
Secretory products of macrophages.
1987,
Pubmed
Perry,
The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration.
1987,
Pubmed
Perry,
Macrophages and the nervous system.
1991,
Pubmed
Phillips,
Biphasic cellular response to transection in the newt optic nerve: glial reactivity precedes axonal degeneration.
1991,
Pubmed
Reier,
Regeneration and remyelination of Xenopus tadpole optic nerve fibres following transection or crush.
1974,
Pubmed
,
Xenbase
Schwab,
Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro.
1988,
Pubmed
Silver,
Guidance of optic axons in vivo by a preformed adhesive pathway on neuroepithelial endfeet.
1984,
Pubmed
So,
Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats.
1985,
Pubmed
Stelzner,
A quantitative analysis of frog optic nerve regeneration: is retrograde ganglion cell death or collateral axonal loss related to selective reinnervation?
1986,
Pubmed
Stensaas,
Axon regeneration across the site of injury in the optic nerve of the newt Triturus pyrrhogaster.
1977,
Pubmed
Stoll,
Macrophage function during Wallerian degeneration of rat optic nerve: clearance of degenerating myelin and Ia expression.
1989,
Pubmed
Stolz,
Macrophages direct process elongation from adult frog motorneurons in culture.
1991,
Pubmed
Taylor,
The induction of an anomalous ipsilateral retinotectal projection in Xenopus laevis.
1990,
Pubmed
,
Xenbase
Taylor,
Fibre organization and reorganization in the retinotectal projection of Xenopus.
1987,
Pubmed
,
Xenbase
Turner,
Non-glial phagocytes within the degenerating optic nerve of the newt (Triturus viridescens).
1975,
Pubmed
Turner,
The ultrastructure of Wallerian degeneration in the severed optic nerve of the newt (Triturus viridescens).
1975,
Pubmed
Turner,
The early stages of Wallerian degeneration in the severed optic nerve of the newt (Triturus viridescens).
1977,
Pubmed
Turner,
The ultrastructure of regeneration in the severed newt optic nerve.
1974,
Pubmed
VAN CREVEL,
THE RATE OF SECONDARY DEGENERATION IN THE CENTRAL NERVOUS SYSTEM. II. THE OPTIC NERVE OF THE CAT.
1963,
Pubmed
Vidal-Sanz,
Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat.
1987,
Pubmed
