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A cDNA clone named 1A11 was isolated in a screen for genes that are activated by both mesoderm inducing factors FGF and activin in animal explants of Xenopus laevis embryos. In undisturbed embryos, 1A11 is expressed during the gastrula stage in the entire marginal zone where mesoderm originates, and later in the somites, the tailbud, and at much lower levels in lateralmesoderm. The 1A11 sequence of 4.5 Kb has a 220 bp repeat at its ends, indicative of a retrotransposon-like structure. A long open reading frame encodes a predicted protein with only short homologies to the gag and protease regions of retroviruses and retrotransposons. Multiple copies of 1A11-related sequences were found in the Xenopus genome, constituting solo LTRs (long terminal repeats) of 1267 bp, and unique region copies (i.e., sequences internal to the repeats in the cDNA). Inverted repeats of 5 bp and apparent target site duplications of 5 bp surround the sequenced solo LTR. Thus, 1A11 is a new retrotransposon-like element in Xenopus laevis.
Bisbee,
Albumin phylogeny for clawed frogs (Xenopus).
1977, Pubmed,
Xenbase
Bisbee,
Albumin phylogeny for clawed frogs (Xenopus).
1977,
Pubmed
,
Xenbase
Blumberg,
Organizer-specific homeobox genes in Xenopus laevis embryos.
1991,
Pubmed
,
Xenbase
Boeke,
Retrotransposition mechanisms.
1991,
Pubmed
Church,
Genomic sequencing.
1984,
Pubmed
Devereux,
A comprehensive set of sequence analysis programs for the VAX.
1984,
Pubmed
Edelmann,
A recombination hotspot in the LTR of a mouse retrotransposon identified in an in vitro system.
1989,
Pubmed
Fanning,
The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins.
1987,
Pubmed
Flavell,
Ty1-copia group retrotransposons are ubiquitous and heterogeneous in higher plants.
1992,
Pubmed
Flavell,
Extreme heterogeneity of Ty1-copia group retrotransposons in plants.
1992,
Pubmed
Flavell,
A Ty1-copia group retrotransposon sequence in a vertebrate.
1992,
Pubmed
Flügel,
Nucleotide sequence analysis of a cloned DNA fragment from human cells reveals homology to retrotransposons.
1987,
Pubmed
Friesel,
Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development.
1992,
Pubmed
,
Xenbase
Fulton,
Upstream and downstream transcriptional control signals in the yeast retrotransposon, TY.
1988,
Pubmed
Garrett,
Tx1: a transposable element from Xenopus laevis with some unusual properties.
1986,
Pubmed
,
Xenbase
Garrett,
Composite transposable elements in the Xenopus laevis genome.
1989,
Pubmed
,
Xenbase
Harland,
In situ hybridization: an improved whole-mount method for Xenopus embryos.
1991,
Pubmed
,
Xenbase
Kay,
The 1723 element: a long, homogeneous, highly repeated DNA unit interspersed in the genome of Xenopus laevis.
1983,
Pubmed
,
Xenbase
Kuff,
Intracisternal A-particle genes as movable elements in the mouse genome.
1983,
Pubmed
Liao,
The upstream activation site of a Ty2 element of yeast is necessary but not sufficient to promote maximal transcription of the element.
1987,
Pubmed
Marlor,
The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins.
1986,
Pubmed
Martens,
Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis.
,
Pubmed
,
Xenbase
Mount,
Complete nucleotide sequence of the Drosophila transposable element copia: homology between copia and retroviral proteins.
1985,
Pubmed
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Paulson,
A transposon-like element in human DNA.
,
Pubmed
Richter,
Gene expression in the embryonic nervous system of Xenopus laevis.
1988,
Pubmed
,
Xenbase
Rosa,
Accumulation and decay of DG42 gene products follow a gradient pattern during Xenopus embryogenesis.
1988,
Pubmed
,
Xenbase
Rosa,
Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos.
1989,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Sato,
Localized and inducible expression of Xenopus-posterior (Xpo), a novel gene active in early frog embryos, encoding a protein with a 'CCHC' finger domain.
1991,
Pubmed
,
Xenbase
Schmidt,
Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).
1984,
Pubmed
Smith,
Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.
1991,
Pubmed
,
Xenbase
Smith,
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.
1990,
Pubmed
,
Xenbase
Taira,
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.
1992,
Pubmed
,
Xenbase
Xiong,
Similarity of reverse transcriptase-like sequences of viruses, transposable elements, and mitochondrial introns.
1988,
Pubmed
Xiong,
Origin and evolution of retroelements based upon their reverse transcriptase sequences.
1990,
Pubmed
